Bacteriocinogeny in experimental pigs treated with short-term
high-dose indomethacin with or without probiotic bacteria
Escherichia coli Nissle 1917

J 2011

Bacteriocinogeny in experimental pigs treated with short-term high-dose indomethacin with or without probiotic bacteria Escherichia coli Nissle 1917

BUREŠ, Jan, David ŠMAJS, Jaroslav KVĚTINA, Miroslav FŐRSTL, Jan ŠMARDA et. al.

Basic information

Original name

Bacteriocinogeny in experimental pigs treated with short-term high-dose indomethacin with or without probiotic bacteria Escherichia coli Nissle 1917

Authors

BUREŠ, Jan (203 Czech Republic, guarantor, belonging to the institution), David ŠMAJS (203 Czech Republic, belonging to the institution), Jaroslav KVĚTINA (203 Czech Republic), Miroslav FŐRSTL (203 Czech Republic), Jan ŠMARDA (203 Czech Republic, belonging to the institution), Darina KOHOUTOVÁ (203 Czech Republic), Martin KUNEŠ (203 Czech Republic), Jiří CYRANY (203 Czech Republic), Ilja TACHECÍ (203 Czech Republic), Stanislav REJCHRT (203 Czech Republic), Jiřina LESNÁ (203 Czech Republic), Viktor VOŘÍŠEK (203 Czech Republic) and Marcela KOPÁČOVÁ (203 Czech Republic, belonging to the institution)

Edition

Wourld Journal of Gastroenterology, China, 2011, 1007-9327

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

China

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.471

RIV identification code

RIV/00216224:14110/11:00051585

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3748/wjg.v17.i5.609

UT WoS

000287627700008

Keywords in English

Bacteriocinogeny; Escherichia coli Nissle 1917; Experimental pigs; Indomethacin

Abstract

V originále

AIM: To evaluate bacteriocinogeny in short-term high-dose indomethacin administration with or without probiotic Escherichia coli Nissle 1917 (EcN) in experimental pigs. METHODS: Twenty-four pigs entered the study: Group A (controls), Group B (probiotics alone), Group C (indomethacin alone) and Group D (probiotics and indomethacin). EcN (3.5x1010 bacteria/d for 14 d) and/or indomethacin (15 mg/kg per day for 10 d) were administrated orally. Anal smears before and smears from the small and large intestine were taken from all animals. Bacteriocin production was determined with 6 different indicator strains. RESULTS: The general microbiota profile was rather uniform in all animals but there was a broad diversity in coliform bacteria (parallel genotypes A, B1, B2 and D found). CONCLUSION: EcN did not exert long-term liveability in the porcine intestine. All experimental pigs remained methanogenic. Indomethacin and EcN administered together might produce the worst impact on bacteriocinogeny.

Links

MSM0021622415, plan (intention)

Name: Molekulární podstata buněčných a tkáňových regulací

Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations

NS9665, research and development project

Name: Molekulární typizace bakteriocinů produkovaných kmeny Escherichia coli z klinického materiálu: identifikace kolicinů a mikrocinů v souborech komensálních a patogenních kmenů

Investor: Ministry of Health of the CR

Citovat

BUREŠ, Jan, David ŠMAJS, Jaroslav KVĚTINA, Miroslav FŐRSTL, Jan ŠMARDA, Darina KOHOUTOVÁ, Martin KUNEŠ, Jiří CYRANY, Ilja TACHECÍ, Stanislav REJCHRT, Jiřina LESNÁ, Viktor VOŘÍŠEK and Marcela KOPÁČOVÁ. Bacteriocinogeny in experimental pigs treated with short-term high-dose indomethacin with or without probiotic bacteria Escherichia coli Nissle 1917. Wourld Journal of Gastroenterology. China, 2011, vol. 17, No 5, p. 609-617. ISSN 1007-9327. Available from: https://dx.doi.org/10.3748/wjg.v17.i5.609.

@article{913361,
   author = {Bureš, Jan and Šmajs, David and Květina, Jaroslav and Főrstl, Miroslav and Šmarda, Jan and Kohoutová, Darina and Kuneš, Martin and Cyrany, Jiří and Tachecí, Ilja and Rejchrt, Stanislav and Lesná, Jiřina and Voříšek, Viktor and Kopáčová, Marcela},
   article_location = {China},
   article_number = {5},
   doi = {http://dx.doi.org/10.3748/wjg.v17.i5.609},
   keywords = {Bacteriocinogeny; Escherichia coli Nissle 1917; Experimental pigs; Indomethacin},
   language = {eng},
   issn = {1007-9327},
   journal = {Wourld Journal of Gastroenterology},
   title = {Bacteriocinogeny in experimental pigs treated with short-term high-dose indomethacin with or without probiotic bacteria Escherichia coli Nissle 1917},
   volume = {17},
   year = {2011}
}

TY  - JOUR
ID  - 913361
AU  - Bureš, Jan - Šmajs, David - Květina, Jaroslav - Főrstl, Miroslav - Šmarda, Jan - Kohoutová, Darina - Kuneš, Martin - Cyrany, Jiří - Tachecí, Ilja - Rejchrt, Stanislav - Lesná, Jiřina - Voříšek, Viktor - Kopáčová, Marcela
PY  - 2011
TI  - Bacteriocinogeny in experimental pigs treated with short-term high-dose indomethacin with or without probiotic bacteria Escherichia coli Nissle 1917
JF  - Wourld Journal of Gastroenterology
VL  - 17
IS  - 5
SP  - 609-617
EP  - 609-617
SN  - 10079327
KW  - Bacteriocinogeny
KW  - Escherichia coli Nissle 1917
KW  - Experimental pigs
KW  - Indomethacin
N2  - AIM: To evaluate bacteriocinogeny in short-term high-dose indomethacin administration with or without probiotic Escherichia coli Nissle 1917 (EcN) in experimental pigs. METHODS: Twenty-four pigs entered the study: Group A (controls), Group B (probiotics alone), Group C (indomethacin alone) and Group D (probiotics and indomethacin). EcN (3.5x1010 bacteria/d for 14 d) and/or indomethacin (15 mg/kg per day for 10 d) were administrated orally. Anal smears before and smears from the small and large intestine were taken from all animals. Bacteriocin production was determined with 6 different indicator strains. RESULTS: The general microbiota profile was rather uniform in all animals but there was a broad diversity in coliform bacteria (parallel genotypes A, B1, B2 and D found). CONCLUSION: EcN did not exert long-term liveability in the porcine intestine. All experimental pigs remained methanogenic. Indomethacin and EcN administered together might produce the worst impact on bacteriocinogeny.
ER  -

BUREŠ, Jan, David ŠMAJS, Jaroslav KVĚTINA, Miroslav F$\backslash$H ORSTL, Jan ŠMARDA, Darina KOHOUTOVÁ, Martin KUNEŠ, Jiří CYRANY, Ilja TACHECÍ, Stanislav REJCHRT, Jiřina LESNÁ, Viktor VOŘÍŠEK and Marcela KOPÁČOVÁ. Bacteriocinogeny in experimental pigs treated with short-term high-dose indomethacin with or without probiotic bacteria Escherichia coli Nissle 1917. \textit{Wourld Journal of Gastroenterology}. China, 2011, vol.~17, No~5, p.~609-617. ISSN~1007-9327. Available from: https://dx.doi.org/10.3748/wjg.v17.i5.609.

Detailed Information on Publication Record