a 2010

Effect of BAPTA and EGTA on inactivation of ICa in a model of rat ventricular myocyte

PÁSEK, Michal, Jiří ŠIMURDA and Clive ORCHARD

Basic information

Original name

Effect of BAPTA and EGTA on inactivation of ICa in a model of rat ventricular myocyte

Name in Czech

Účinek BAPTA a EGTA na inaktivaci ICa v modelu srdeční komorové buňky potkana

Authors

PÁSEK, Michal (203 Czech Republic, guarantor), Jiří ŠIMURDA (203 Czech Republic, belonging to the institution) and Clive ORCHARD (826 United Kingdom of Great Britain and Northern Ireland)

Edition

Analysis of Biomedical Signals and Images, 2010

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

10610 Biophysics

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/10:00045971

Organization unit

Faculty of Medicine

ISBN

978-80-214-4105-7

Keywords in English

cardiac cell; BAPTA; EGTA; calcium current; quantitative model

Tags

International impact, Reviewed
Změněno: 30/12/2012 18:04, doc. Ing. Michal Pásek, Ph.D.

Abstract

V originále

An existing model of the rat ventricular myocyte was modified to reproduce the experimentally observed differential effects of the fast and slow exogenous Ca2+ buffers BAPTA and EGTA on inactivation of ICa and to investigate the possible cause. The results of the simulations suggest that the different potencies of EGTA and BAPTA on inactivation of ICa are due to their different rates of Ca2+ binding, and thus different intracellular gradients of bound and unbound buffer, causing different rates of diffusion of bound and unbound buffer out of and into the dyadic space. The consequent difference in suppression of the Ca2+ transient in the dyadic space caused different rates of Ca2+ - induced inactivation of ICa in the presence of the two buffers.

Links

MSM0021622402, plan (intention)
Name: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases