| RÁČIL, Zdeněk, Filip RÁZGA, Kateřina MACHOVÁ POLÁKOVÁ, Lucie BUREŠOVÁ, Václava POLÍVKOVÁ, Dana DVOŘÁKOVÁ, Daniela ŽÁČKOVÁ, Hana KLAMOVÁ, Petr CETKOVSKÝ and Jiří MAYER. Assessment of adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1) mRNA expression in patients with de novo chronic myelogenous leukemia: the role of different cell types. Leukemia & Lymphoma. London: Informa UK, Ltd., 2011, vol. 52, No 2, p. 331-334. ISSN 1042-8194. Available from: https://dx.doi.org/10.3109/10428194.2010.533220. |
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@article{914486,
author = {Ráčil, Zdeněk and Rázga, Filip and Machová Poláková, Kateřina and Burešová, Lucie and Polívková, Václava and Dvořáková, Dana and Žáčková, Daniela and Klamová, Hana and Cetkovský, Petr and Mayer, Jiří},
article_location = {London},
article_number = {2},
doi = {http://dx.doi.org/10.3109/10428194.2010.533220},
keywords = {mRNA exprese; CML},
language = {eng},
issn = {1042-8194},
journal = {Leukemia & Lymphoma},
title = {Assessment of adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1) mRNA expression in patients with de novo chronic myelogenous leukemia: the role of different cell types.},
volume = {52},
year = {2011}
}
TY - JOUR
ID - 914486
AU - Ráčil, Zdeněk - Rázga, Filip - Machová Poláková, Kateřina - Burešová, Lucie - Polívková, Václava - Dvořáková, Dana - Žáčková, Daniela - Klamová, Hana - Cetkovský, Petr - Mayer, Jiří
PY - 2011
TI - Assessment of adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1) mRNA expression in patients with de novo chronic myelogenous leukemia: the role of different cell types.
JF - Leukemia & Lymphoma
VL - 52
IS - 2
SP - 331-334
EP - 331-334
PB - Informa UK, Ltd.
SN - 10428194
KW - mRNA exprese
KW - CML
N2 - In this study, we investigated differences in ABCB1 mRNA expression measured in peripheral blood (PB) leukocytes (LEU) as well as polymorphonuclear (PMNCs) and mononuclear cells (MNCs) of PB LEU obtained from healthy volunteers and patients with de novo CML. In addition, we analyzed the relationship between the percentage of individual cells that comprise the total LEU count and ABCB1 mRNA expression assessed from the total LEU. We have shown that ABCB1 mRNA transcript levels are significantly higher in PB MNCs than in PB PMNCs and are lower in patients with de novo CML compared to healthy individuals. Moreover, we have demonstrated the importance of the cell composition of analyzed samples in ABCB1 mRNA expression analysis.
ER -
RÁČIL, Zdeněk, Filip RÁZGA, Kateřina MACHOVÁ POLÁKOVÁ, Lucie BUREŠOVÁ, Václava POLÍVKOVÁ, Dana DVOŘÁKOVÁ, Daniela ŽÁČKOVÁ, Hana KLAMOVÁ, Petr CETKOVSKÝ and Jiří MAYER. Assessment of adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1) mRNA expression in patients with de novo chronic myelogenous leukemia: the role of different cell types. \textit{Leukemia \&{} Lymphoma}. London: Informa UK, Ltd., 2011, vol.~52, No~2, p.~331-334. ISSN~1042-8194. Available from: https://dx.doi.org/10.3109/10428194.2010.533220.
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