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@article{914488,
author = {Ježíšková, Ivana and Rázga, Filip and Bajerová, Monika and Ráčil, Zdeněk and Mayer, Jiří and Dvořáková, Dana},
article_number = {12},
doi = {http://dx.doi.org/10.3109/10428194.2010.523126},
keywords = {acute myeloid leukemia},
language = {eng},
issn = {1042-8194},
journal = {Leukemia & Lymphoma},
title = {IDH2 mutations in patients with acute myeloid leukemia: missense p.R140 mutations are linked to disease status},
volume = {51},
year = {2010}
}
TY - JOUR
ID - 914488
AU - Ježíšková, Ivana - Rázga, Filip - Bajerová, Monika - Ráčil, Zdeněk - Mayer, Jiří - Dvořáková, Dana
PY - 2010
TI - IDH2 mutations in patients with acute myeloid leukemia: missense p.R140 mutations are linked to disease status
JF - Leukemia & Lymphoma
VL - 51
IS - 12
SP - 2285-2287
EP - 2285-2287
PB - Gordon and Breach
SN - 10428194
KW - acute myeloid leukemia
N2 - In conclusion, our data demonstrate that, within the cohort of tested individuals, the IDH2 mutations are associated with AML (in contrast to healthy volunteers), suggesting a role for these mutations in disease pathogenesis. In addition, we show an association of the observed IDH2 mutations with disease status, indicating their potential for MRD monitoring. This report thus indicates that IDH2 p.R140 variants are possible markers for MRD detection. However, an extended investigation of IDH2 mutations kinetics, involving long-term followup and a larger cohort of IDH2 mutated AMLs, will be required to confirm these findings.
ER -
JEŽÍŠKOVÁ, Ivana, Filip RÁZGA, Monika BAJEROVÁ, Zdeněk RÁČIL, Jiří MAYER a Dana DVOŘÁKOVÁ. IDH2 mutations in patients with acute myeloid leukemia: missense p.R140 mutations are linked to disease status. Online. \textit{Leukemia \&{} Lymphoma}. Gordon and Breach, 2010, roč.~51, č.~12, s.~2285-2287. ISSN~1042-8194. Dostupné z: https://dx.doi.org/10.3109/10428194.2010.523126. [citováno 2024-04-23]
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