Striking medium effects on the kinetics of decomposition of
macrocyclic Cu(II) complexes: Additional considerations to be
taken when designing Copper-64 radiopharmaceuticals

J 2010

Striking medium effects on the kinetics of decomposition of macrocyclic Cu(II) complexes: Additional considerations to be taken when designing Copper-64 radiopharmaceuticals

BASALLOTE, Manuel G., Carmen E. CASTILLO, M. Angeles MÁÑEZ, Přemysl LUBAL, Manuel MARTÍNEZ et. al.

Basic information

Original name

Striking medium effects on the kinetics of decomposition of macrocyclic Cu(II) complexes: Additional considerations to be taken when designing Copper-64 radiopharmaceuticals

Authors

BASALLOTE, Manuel G. (724 Spain), Carmen E. CASTILLO (724 Spain), M. Angeles MÁÑEZ (724 Spain), Přemysl LUBAL (203 Czech Republic, belonging to the institution), Manuel MARTÍNEZ (724 Spain, guarantor), Carlos RODRÍGUEZ (724 Spain) and Jakub VANĚK (203 Czech Republic, belonging to the institution)

Edition

Inorganic Chemistry Communications, Netherlands, Elsevier Science, 2010, 1387-7003

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10402 Inorganic and nuclear chemistry

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.974

RIV identification code

RIV/00216224:14310/10:00046232

Organization unit

Faculty of Science

UT WoS

000282867800011

Keywords in English

Decomposition of copper complexes; Kinetics; Electrolyte media; Copper-64 radiopharmaceuticals

Změněno: 3/1/2011 19:25, prof. RNDr. Přemysl Lubal, Ph.D.

Abstract

V originále

The kinetics of decomposition of a macrocyclic Cu2+ complex is strongly dependent on the anions in solution. In particular, chloride anions accelerate significantly the decomposition process, even out of the stopped-flow time scale. Given the different chloride concentrations in biological media, the possibility of changes in the decomposition kinetics must be considered when designing 64Cu radiopharmaceuticals.

Links

MUNI/A/0992/2009, interní kód MU

Name: Vývoj metodologie a instrumentace analytické chemie pro studium složení a vlastností přírodních a syntetických materiálů (Acronym: MIA)

Investor: Masaryk University, Category A

OC 179, research and development project

Name: Molekulární zobrazování založené na systémech obsahujících kovy.

Citovat

BASALLOTE, Manuel G., Carmen E. CASTILLO, M. Angeles MÁÑEZ, Přemysl LUBAL, Manuel MARTÍNEZ, Carlos RODRÍGUEZ and Jakub VANĚK. Striking medium effects on the kinetics of decomposition of macrocyclic Cu(II) complexes: Additional considerations to be taken when designing Copper-64 radiopharmaceuticals. Inorganic Chemistry Communications. Netherlands: Elsevier Science, 2010, vol. 13, No 11, p. 1272-1274. ISSN 1387-7003.

@article{916085,
   author = {Basallote, Manuel G. and Castillo, Carmen E. and Máñez, M. Angeles and Lubal, Přemysl and Martínez, Manuel and Rodríguez, Carlos and Vaněk, Jakub},
   article_location = {Netherlands},
   article_number = {11},
   keywords = {Decomposition of copper complexes; Kinetics; Electrolyte media; Copper-64 radiopharmaceuticals},
   language = {eng},
   issn = {1387-7003},
   journal = {Inorganic Chemistry Communications},
   title = {Striking medium effects on the kinetics of decomposition of macrocyclic Cu(II) complexes: Additional considerations to be taken when designing Copper-64 radiopharmaceuticals},
   url = {http://linkinghub.elsevier.com/retrieve/pii/S1387700310003084},
   volume = {13},
   year = {2010}
}

TY  - JOUR
ID  - 916085
AU  - Basallote, Manuel G. - Castillo, Carmen E. - Máñez, M. Angeles - Lubal, Přemysl - Martínez, Manuel - Rodríguez, Carlos - Vaněk, Jakub
PY  - 2010
TI  - Striking medium effects on the kinetics of decomposition of macrocyclic Cu(II) complexes: Additional considerations to be taken when designing Copper-64 radiopharmaceuticals
JF  - Inorganic Chemistry Communications
VL  - 13
IS  - 11
SP  - 1272-1274
EP  - 1272-1274
PB  - Elsevier Science
SN  - 13877003
KW  - Decomposition of copper complexes
KW  - Kinetics
KW  - Electrolyte media
KW  - Copper-64 radiopharmaceuticals
UR  - http://linkinghub.elsevier.com/retrieve/pii/S1387700310003084
N2  - The kinetics of decomposition of a macrocyclic Cu2+ complex is strongly dependent on the anions in solution. In particular, chloride anions accelerate significantly the decomposition process, even out of the stopped-flow time scale. Given the different chloride concentrations in biological media, the possibility of changes in the decomposition kinetics must be considered when designing 64Cu radiopharmaceuticals.
ER  -

BASALLOTE, Manuel G., Carmen E. CASTILLO, M. Angeles MÁÑEZ, Přemysl LUBAL, Manuel MARTÍNEZ, Carlos RODRÍGUEZ and Jakub VANĚK. Striking medium effects on the kinetics of decomposition of macrocyclic Cu(II) complexes: Additional considerations to be taken when designing Copper-64 radiopharmaceuticals. \textit{Inorganic Chemistry Communications}. Netherlands: Elsevier Science, 2010, vol.~13, No~11, p.~1272-1274. ISSN~1387-7003.

Detailed Information on Publication Record