The authors present a complicated case of tuberculosis in an immunocompromised female patient after a liver transplantation with a permanent immunosuppressive therapy. The patient was admitted in serious condition to the Clinic of Respiratory Diseases and TBC due to tuberculosis of peritoneum and liver. During the hospitalization the tuberculosis of the intestine, the right eye, miliar pulmonary tuberculosis, and TBC pleuritis were diagnosed. On the treatment a quadrucombination of antituberculotics the originally serious health condition started to improve gradually, control samples were repeatedly negative for mycobacteria and the patient was discharged to the out-patient care.