Successful treatment of life-threatening Candida peritonitis in a child with abdominal non-Hodgkin lymphoma using Efungumab and amphotericin B colloid dispersion.

KŘENOVÁ, Zdenka, Zdeněk PAVELKA, Petr LOKAJ, Jarmila SKOTÁKOVÁ, Iva KOCMANOVÁ, Otakar TEYSCHL, Leoš KŘEN, Peter MÚDRY and Jaroslav ŠTĚRBA. Successful treatment of life-threatening Candida peritonitis in a child with abdominal non-Hodgkin lymphoma using Efungumab and amphotericin B colloid dispersion. Journal of Pediatric Hematology and Oncology. U.S.A.: Lippincot, 2010, vol. 32, No 2, p. 128-130. ISSN 1077-4114.

Basic information

• Original name: Successful treatment of life-threatening Candida peritonitis in a child with abdominal non-Hodgkin lymphoma using Efungumab and amphotericin B colloid dispersion.
• Name in Czech: Úspěšná léčba život ohrožující kandidové peritonitidy u dítěte s non-Hodgkinským lymfomem Efungumabem a amfotericinem B v koloidní disperzi.
• Authors: KŘENOVÁ, Zdenka (203 Czech Republic, guarantor, belonging to the institution), Zdeněk PAVELKA (203 Czech Republic, belonging to the institution), Petr LOKAJ (203 Czech Republic, belonging to the institution), Jarmila SKOTÁKOVÁ (203 Czech Republic, belonging to the institution), Iva KOCMANOVÁ (203 Czech Republic, belonging to the institution), Otakar TEYSCHL (203 Czech Republic, belonging to the institution), Leoš KŘEN (203 Czech Republic, belonging to the institution), Peter MÚDRY (203 Czech Republic, belonging to the institution) and Jaroslav ŠTĚRBA (203 Czech Republic, belonging to the institution).
• Edition: Journal of Pediatric Hematology and Oncology, U.S.A. Lippincot, 2010, 1077-4114.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 0.998
• RIV identification code: RIV/00216224:14110/10:00046351
• Organization unit: Faculty of Medicine
• UT WoS: 000275559800011
• Keywords (in Czech): kandidová peritonitida Efungumad amfotericin B koloidní disperze
• Keywords in English: Candica peritonitis Efungumab amphotericin B colloid dispersion

Abstract

Invasive fungal infections are serious complications of cancer therapy. We present a case report of a 12-year-old boy diagnosed with abdominal non-Hodgkin lymphoma and fecal and Candida peritonitis during induction chemotherapy. The invasive mycosis was managed using a combined approach of systemic antifungal agents including efungumab and surgical interventions. Efungumab, a recombinant antibody that inhibits extracellular heat shock protein 90, was used in combination with amphotericin B colloid dispersion after the failure of standard approaches.

Abstract (in Czech)

Článek informuje o úspěšné léčbě život ohrožující kandidové peritonitidy u pacienta s non-Hodgkinským lymfomem užitím Efungumabu a amfotericinu B v koloidní disperzi.