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@inproceedings{917154,
author = {Ďurech, Michal and Adam, Jan and Pokorná, Marie and Šulák, Ondřej and Koča, Jaroslav and Wimmerová, Michaela},
address = {Brno},
booktitle = {XIV. Setkání biochemiků a molekulárních biologů},
keywords = {molecular modeling; lectin-saccharide interaction; functional studies},
language = {eng},
location = {Brno},
isbn = {978-80-210-5164-5},
pages = {50-50},
publisher = {Masarykova Univerzita},
title = {Functional studies of Ralstonia solanacearum lectin RS20L},
year = {2010}
}
TY - JOUR
ID - 917154
AU - Ďurech, Michal - Adam, Jan - Pokorná, Marie - Šulák, Ondřej - Koča, Jaroslav - Wimmerová, Michaela
PY - 2010
TI - Functional studies of Ralstonia solanacearum lectin RS20L
PB - Masarykova Univerzita
CY - Brno
SN - 9788021051645
KW - molecular modeling
KW - lectin-saccharide interaction
KW - functional studies
N2 - This work is focused on Ralstonia solanacearum lectin RS20L. R. solanacearum is a plant bacterial pathogen, which is responsible for wilt disease in many economically important crops such as banana, tobacco, potatoes, peppers, etc., leading to agricultural losses and famine. The RS20L lectin displays no sequence similarity to any known amino acid sequence. Functional analysis could contribute to understanding of different specificity of Ralstonia solanacearum lectins and help to describe virulence potential of this plant pathogen. Revealing saccharide specificity and mechanism of lectin recognition could serve as a starting point in designing sugar analogs or other efficient inhibitors that avoid bacterial adherence to host cell. Experimental attempts of lectin functional characterization follow up the molecular modelling studies [1] that gave us a theoretical background in generating several hypotheses during the experimental investigation of the lectin’s function.
ER -
ĎURECH, Michal, Jan ADAM, Marie POKORNÁ, Ondřej ŠULÁK, Jaroslav KOČA and Michaela WIMMEROVÁ. Functional studies of Ralstonia solanacearum lectin RS20L. In \textit{XIV. Setkání biochemiků a molekulárních biologů}. Brno: Masarykova Univerzita, 2010, p.~50. ISBN~978-80-210-5164-5.
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