D 2010

Functional studies of Ralstonia solanacearum lectin RS20L

ĎURECH, Michal, Jan ADAM, Marie POKORNÁ, Ondřej ŠULÁK, Jaroslav KOČA et. al.

Basic information

Original name

Functional studies of Ralstonia solanacearum lectin RS20L

Name in Czech

Functional studies of Ralstonia solanacearum lectin RS20L

Authors

ĎURECH, Michal, Jan ADAM, Marie POKORNÁ, Ondřej ŠULÁK, Jaroslav KOČA and Michaela WIMMEROVÁ

Edition

Brno, XIV. Setkání biochemiků a molekulárních biologů, p. 50-50, 2010

Publisher

Masarykova Univerzita

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

10600 1.6 Biological sciences

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Science

ISBN

978-80-210-5164-5

Keywords (in Czech)

molecular modeling; lectin-saccharide interaction; functional studies

Keywords in English

molecular modeling; lectin-saccharide interaction; functional studies
Změněno: 8/1/2011 18:03, Mgr. Michal Ďurech, Ph.D.

Abstract

ORIG CZ

V originále

This work is focused on Ralstonia solanacearum lectin RS20L. R. solanacearum is a plant bacterial pathogen, which is responsible for wilt disease in many economically important crops such as banana, tobacco, potatoes, peppers, etc., leading to agricultural losses and famine. The RS20L lectin displays no sequence similarity to any known amino acid sequence. Functional analysis could contribute to understanding of different specificity of Ralstonia solanacearum lectins and help to describe virulence potential of this plant pathogen. Revealing saccharide specificity and mechanism of lectin recognition could serve as a starting point in designing sugar analogs or other efficient inhibitors that avoid bacterial adherence to host cell. Experimental attempts of lectin functional characterization follow up the molecular modelling studies [1] that gave us a theoretical background in generating several hypotheses during the experimental investigation of the lectin’s function.

In Czech

Práce se zabývá lektinem RS20L z fytopatogenu Ralstonia solanacearum. Lektin nevykazuje žádnou sekvenční podobnost na aminokyselinové ani nukleotidové úrovni. Funkční studie vazebných vlastností lektinu by mohly pomoci k pochopení specifity lektinu a popisu virulentního potenciálu tohoto patogenu. Experimentální studie vycházejí z výsledků metod molekulového modelování.

Links

GA303/09/1168, research and development project
Name: Lektiny z lidských patogenů - struktura, funkce, inženýrství
Investor: Czech Science Foundation, Lectins from human pathogens - structure, function, engineering
MSM0021622413, plan (intention)
Name: Proteiny v metabolismu a při interakci organismů s prostředím
Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment