DEOXYSCHIZANDRIN AND GAMMA-SCHIZANDRIN RESTORE THE CYTOTOXIC
ACTION OF DOXORUBICIN IN MULTI-DRUG RESISTANT LUNG CANCER CELLS
COR-L23/R

C 2010

DEOXYSCHIZANDRIN AND GAMMA-SCHIZANDRIN RESTORE THE CYTOTOXIC ACTION OF DOXORUBICIN IN MULTI-DRUG RESISTANT LUNG CANCER CELLS COR-L23/R

SLANINA, Jiří, Lenka ADÁMKOVÁ, Ludmila KOUBÍKOVÁ, Jindřiška HAMMEROVÁ, Iva SLANINOVÁ et. al.

Basic information

Original name

DEOXYSCHIZANDRIN AND GAMMA-SCHIZANDRIN RESTORE THE CYTOTOXIC ACTION OF DOXORUBICIN IN MULTI-DRUG RESISTANT LUNG CANCER CELLS COR-L23/R

Name in Czech

Deoxyschizandrin a gama-schizandrin obnovují cytotoxický účinek doxorubicinu na rezistentní buňky plicního karcinomu COR-L23/R

Authors

SLANINA, Jiří (203 Czech Republic, guarantor, belonging to the institution), Lenka ADÁMKOVÁ (203 Czech Republic, belonging to the institution), Ludmila KOUBÍKOVÁ (203 Czech Republic, belonging to the institution), Jindřiška HAMMEROVÁ (203 Czech Republic, belonging to the institution) and Iva SLANINOVÁ (203 Czech Republic, belonging to the institution)

Edition

1st. Cambridge, Functional Molecules from Natural Sources, p. 140-145, 6 pp. Special Publication No. 320, 2010

Publisher

The Royal Society of Chemistry

Other information

Language

English

Type of outcome

Kapitola resp. kapitoly v odborné knize

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/10:00049176

Organization unit

Faculty of Medicine

ISBN

978-1-84755-259-4

Keywords (in Czech)

Schisandra chinensis; Schisandraceae; dibenzocyklooktadienové lignany; cytotoxicita; apoptóza

Keywords in English

Schisandra chinensis; Schisandraceae; dibenzocyclooctadiene lignans; cytotoxicity; apoptosis

Změněno: 8/1/2011 23:33, Mgr. Jiří Slanina, Ph.D.

Abstract

ORIG CZ

V originále

We found that the lignans R-(+)-deoxyschizandrin and R,S-gamma-schizandrin restored the cytotoxic action of the MRP1 substrate doxorubicin to COR-L23/R cells at relatively non-toxic concentrations of the lignans. Deoxyschizandrin and gamma-schizandrin also showed the greatest propensity to enhance the accumulation of doxorubicin in drug resistant cells.

In Czech

Zjistili jsme, že lignany R-(+)-deoxyschizandrin and R,S-gama-schizandrin obnovují cytotoxický účinek MRP1 substrátu doxorubicinu na buňky COR-L23/R v relativně netoxických koncentracích.

Links

GA522/07/0995, research and development project

Name: Regulace biosyntézy sekundarních metabolitů v buněčné kultuře Schisandra chinensis

Investor: Czech Science Foundation

Citovat

SLANINA, Jiří, Lenka ADÁMKOVÁ, Ludmila KOUBÍKOVÁ, Jindřiška HAMMEROVÁ and Iva SLANINOVÁ. DEOXYSCHIZANDRIN AND GAMMA-SCHIZANDRIN RESTORE THE CYTOTOXIC ACTION OF DOXORUBICIN IN MULTI-DRUG RESISTANT LUNG CANCER CELLS COR-L23/R. In Functional Molecules from Natural Sources. 1st. Cambridge: The Royal Society of Chemistry, 2010, p. 140-145. Special Publication No. 320. ISBN 978-1-84755-259-4.

@inbook{917578,
   author = {Slanina, Jiří and Adámková, Lenka and Koubíková, Ludmila and Hammerová, Jindřiška and Slaninová, Iva},
   address = {Cambridge},
   booktitle = {Functional Molecules from Natural Sources},
   edition = {1st},
   keywords = {Schisandra chinensis; Schisandraceae; dibenzocyclooctadiene lignans; cytotoxicity; apoptosis},
   language = {eng},
   location = {Cambridge},
   isbn = {978-1-84755-259-4},
   pages = {140-145},
   publisher = {The Royal Society of Chemistry},
   title = {DEOXYSCHIZANDRIN AND GAMMA-SCHIZANDRIN RESTORE THE CYTOTOXIC ACTION OF DOXORUBICIN IN MULTI-DRUG RESISTANT LUNG CANCER CELLS COR-L23/R},
   year = {2010}
}

TY  - CHAP
ID  - 917578
AU  - Slanina, Jiří - Adámková, Lenka - Koubíková, Ludmila - Hammerová, Jindřiška - Slaninová, Iva
PY  - 2010
TI  - DEOXYSCHIZANDRIN AND GAMMA-SCHIZANDRIN RESTORE THE CYTOTOXIC ACTION OF DOXORUBICIN IN MULTI-DRUG RESISTANT LUNG CANCER CELLS COR-L23/R
VL  - Special Publication No. 320
PB  - The Royal Society of Chemistry
CY  - Cambridge
SN  - 9781847552594
KW  - Schisandra chinensis
KW  - Schisandraceae
KW  - dibenzocyclooctadiene lignans
KW  - cytotoxicity
KW  - apoptosis
N2  - We found that the lignans R-(+)-deoxyschizandrin and R,S-gamma-schizandrin restored the cytotoxic action of the MRP1 substrate doxorubicin to COR-L23/R cells at relatively non-toxic concentrations of the lignans. Deoxyschizandrin and gamma-schizandrin also showed the greatest propensity to enhance the accumulation of doxorubicin in drug resistant cells.
ER  -

SLANINA, Jiří, Lenka ADÁMKOVÁ, Ludmila KOUBÍKOVÁ, Jindřiška HAMMEROVÁ and Iva SLANINOVÁ. DEOXYSCHIZANDRIN AND GAMMA-SCHIZANDRIN RESTORE THE CYTOTOXIC ACTION OF DOXORUBICIN IN MULTI-DRUG RESISTANT LUNG CANCER CELLS COR-L23/R. In \textit{Functional Molecules from Natural Sources}. 1st. Cambridge: The Royal Society of Chemistry, 2010, p.~140-145. Special Publication No. 320. ISBN~978-1-84755-259-4.

Detailed Information on Publication Record