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@inbook{917578, author = {Slanina, Jiří and Adámková, Lenka and Koubíková, Ludmila and Hammerová, Jindřiška and Slaninová, Iva}, address = {Cambridge}, booktitle = {Functional Molecules from Natural Sources}, edition = {1st}, keywords = {Schisandra chinensis; Schisandraceae; dibenzocyclooctadiene lignans; cytotoxicity; apoptosis}, language = {eng}, location = {Cambridge}, isbn = {978-1-84755-259-4}, pages = {140-145}, publisher = {The Royal Society of Chemistry}, title = {DEOXYSCHIZANDRIN AND GAMMA-SCHIZANDRIN RESTORE THE CYTOTOXIC ACTION OF DOXORUBICIN IN MULTI-DRUG RESISTANT LUNG CANCER CELLS COR-L23/R}, year = {2010} }
TY - CHAP ID - 917578 AU - Slanina, Jiří - Adámková, Lenka - Koubíková, Ludmila - Hammerová, Jindřiška - Slaninová, Iva PY - 2010 TI - DEOXYSCHIZANDRIN AND GAMMA-SCHIZANDRIN RESTORE THE CYTOTOXIC ACTION OF DOXORUBICIN IN MULTI-DRUG RESISTANT LUNG CANCER CELLS COR-L23/R VL - Special Publication No. 320 PB - The Royal Society of Chemistry CY - Cambridge SN - 9781847552594 KW - Schisandra chinensis KW - Schisandraceae KW - dibenzocyclooctadiene lignans KW - cytotoxicity KW - apoptosis N2 - We found that the lignans R-(+)-deoxyschizandrin and R,S-gamma-schizandrin restored the cytotoxic action of the MRP1 substrate doxorubicin to COR-L23/R cells at relatively non-toxic concentrations of the lignans. Deoxyschizandrin and gamma-schizandrin also showed the greatest propensity to enhance the accumulation of doxorubicin in drug resistant cells. ER -
SLANINA, Jiří, Lenka ADÁMKOVÁ, Ludmila KOUBÍKOVÁ, Jindřiška HAMMEROVÁ and Iva SLANINOVÁ. DEOXYSCHIZANDRIN AND GAMMA-SCHIZANDRIN RESTORE THE CYTOTOXIC ACTION OF DOXORUBICIN IN MULTI-DRUG RESISTANT LUNG CANCER CELLS COR-L23/R. In \textit{Functional Molecules from Natural Sources}. 1st. Cambridge: The Royal Society of Chemistry, 2010, p.~140-145. Special Publication No. 320. ISBN~978-1-84755-259-4.
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