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@article{918826,
author = {Janíková, Andrea and Tichý, Boris and Šupíková, Jana and Staňo Kozubík, Kateřina and Pospíšilová, Šárka and Křen, Leoš and Vášová, Ingrid and Šálek, David and Mayer, Jiří},
article_location = {London},
article_number = {1},
doi = {http://dx.doi.org/10.3109/10428194.2010.531412},
keywords = {follicular lymphoma; gene expression profiling; lymphomagenesis; prognosis},
language = {eng},
issn = {1042-8194},
journal = {LEUKEMIA & LYMPHOMA},
title = {Gene expression profiling in follicular lymphoma and its implication for clinical practise},
volume = {52},
year = {2011}
}
TY - JOUR
ID - 918826
AU - Janíková, Andrea - Tichý, Boris - Šupíková, Jana - Staňo Kozubík, Kateřina - Pospíšilová, Šárka - Křen, Leoš - Vášová, Ingrid - Šálek, David - Mayer, Jiří
PY - 2011
TI - Gene expression profiling in follicular lymphoma and its implication for clinical practise
JF - LEUKEMIA & LYMPHOMA
VL - 52
IS - 1
SP - 59-68
EP - 59-68
PB - Informa Healthcare / Leonidas Platanias
SN - 10428194
KW - follicular lymphoma
KW - gene expression profiling
KW - lymphomagenesis
KW - prognosis
N2 - Follicular lymphoma(FL) is characterized by an indolent and relapsing course. Recently, the clinical outcome of FL has been distinguished by immune microenvironment associated gene signatures. In our study, gene expression profiling (GEP) was performed in 31 nonselected patients with follicular lymphoma (FL), 12 of whom were in relapse and the remaining 19 newly diagnosed. A custom oligonucleotide microarray (Agilent 8 x 15K) was used which contained probes for about 3500 genes, including those that had been previously published as demonstrating significant prognostic value. An unsupervised approach was not able to recognize clinically different FLs. As the previously published prognostically relevant gene signatures could not be properly verified, probably due to microarray platform differences, template matching was therefore used in order to define two gene sets with differential gene expression among our samples. These gene sets shared an overrepresentation of genes with similar biological functions and were termed T CELL and PROLIFERATION profiles. The poor profile was then defined by a high PROLIFERATION score (upper tertile) and or low T CELL score (lower tertile). The poor profile cohort contained a significantly higher proportion of relapsed cases (p 0,05 Fishers exact test). Additionally, a comparison of samples from initial diagnosis and from relapse showed significant differences mainly in the T CELL profile (p=0,036 x (2)). This supports the hypothesis that the number of T cells and their expression pattern play a major role in FL development.
ER -
JANÍKOVÁ, Andrea, Boris TICHÝ, Jana ŠUPÍKOVÁ, Kateřina STAŇO KOZUBÍK, Šárka POSPÍŠILOVÁ, Leoš KŘEN, Ingrid VÁŠOVÁ, David ŠÁLEK a Jiří MAYER. Gene expression profiling in follicular lymphoma and its implication for clinical practise. \textit{LEUKEMIA \&{} LYMPHOMA}. London: Informa Healthcare / Leonidas Platanias, roč.~52, č.~1, s.~59-68. ISSN~1042-8194. doi:10.3109/10428194.2010.531412. 2011.
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