Imbalance in T-cell and cytokine profiles in patients with
relapsing-remitting multiple sclerosis

J 2011

Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis

MIKULKOVÁ, Zuzana, Petra PRAKSOVÁ, Pavel ŠTOURAČ, Josef BEDNAŘÍK, Jaroslav MICHÁLEK et. al.

Basic information

Original name

Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis

Authors

MIKULKOVÁ, Zuzana (203 Czech Republic, belonging to the institution), Petra PRAKSOVÁ (203 Czech Republic), Pavel ŠTOURAČ (203 Czech Republic), Josef BEDNAŘÍK (203 Czech Republic) and Jaroslav MICHÁLEK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of the neurological sciences, Netherlands, Amsterdam : Elsevier, 2011, 0022-510X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.353

RIV identification code

RIV/00216224:14740/11:00051674

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.jns.2010.08.053

UT WoS

000286850900025

Keywords (in Czech)

roztroušená skleróza; T lymfocyty; paměťové buňky; cytokiny; průtoková cytometrie

Keywords in English

multiple sclerosis; T-cells; memory cells; cytokines; flow cytometry

Abstract

V originále

In the present study, T-lymphocyte populations and pro-inflammatory as well as suppressive cytokine profiles were evaluated in detail in previously untreated patients with relapsing-remitting multiple sclerosis (RRMS). CD4(+) and CD8(+) naive, central memory (Tcm), effector memory (Tem), terminal effector memory (Ttem), CD4(+) regulatory T-cells (Treg) and CD8(+) T-suppressor cells (Ts) were analysed using flow cytometry, and levels of ten plasma cytokines were determined using fluorescent bead-based immunoassay. We evaluated two groups of RRMS with minor (n=33) and major (n=25) clinical impairment and compared them with healthy controls (n=40) in order to detect any correlation between severity of MS clinical symptoms and immune disturbances. In conclusion, we demonstrate complex immune dysbalances in untreated MS patients.

Links

MSM0021622404, plan (intention)

Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.

Citovat

MIKULKOVÁ, Zuzana, Petra PRAKSOVÁ, Pavel ŠTOURAČ, Josef BEDNAŘÍK and Jaroslav MICHÁLEK. Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis. Journal of the neurological sciences. Netherlands: Amsterdam : Elsevier, 2011, vol. 300, 1-2, p. 135-141. ISSN 0022-510X. Available from: https://dx.doi.org/10.1016/j.jns.2010.08.053.

@article{918900,
   author = {Mikulková, Zuzana and Praksová, Petra and Štourač, Pavel and Bednařík, Josef and Michálek, Jaroslav},
   article_location = {Netherlands},
   article_number = {1-2},
   doi = {http://dx.doi.org/10.1016/j.jns.2010.08.053},
   keywords = {multiple sclerosis; T-cells; memory cells; cytokines; flow cytometry},
   language = {eng},
   issn = {0022-510X},
   journal = {Journal of the neurological sciences},
   title = {Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis},
   volume = {300},
   year = {2011}
}

TY  - JOUR
ID  - 918900
AU  - Mikulková, Zuzana - Praksová, Petra - Štourač, Pavel - Bednařík, Josef - Michálek, Jaroslav
PY  - 2011
TI  - Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis
JF  - Journal of the neurological sciences
VL  - 300
IS  - 1-2
SP  - 135-141
EP  - 135-141
PB  - Amsterdam : Elsevier
SN  - 0022510X
KW  - multiple sclerosis
KW  - T-cells
KW  - memory cells
KW  - cytokines
KW  - flow cytometry
N2  - In the present study, T-lymphocyte populations and pro-inflammatory as well as suppressive cytokine profiles were evaluated in detail in previously untreated patients with relapsing-remitting multiple sclerosis (RRMS). CD4(+) and CD8(+) naive, central memory (Tcm), effector memory (Tem), terminal effector memory (Ttem), CD4(+) regulatory T-cells (Treg) and CD8(+) T-suppressor cells (Ts) were analysed using flow cytometry, and levels of ten plasma cytokines were determined using fluorescent bead-based immunoassay. We evaluated two groups of RRMS with minor (n=33) and major (n=25) clinical impairment and compared them with healthy controls (n=40) in order to detect any correlation between severity of MS clinical symptoms and immune disturbances. In conclusion, we demonstrate complex immune dysbalances in untreated MS patients.
ER  -

MIKULKOVÁ, Zuzana, Petra PRAKSOVÁ, Pavel ŠTOURAČ, Josef BEDNAŘÍK and Jaroslav MICHÁLEK. Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis. \textit{Journal of the neurological sciences}. Netherlands: Amsterdam : Elsevier, 2011, vol.~300, 1-2, p.~135-141. ISSN~0022-510X. Available from: https://dx.doi.org/10.1016/j.jns.2010.08.053.

Detailed Information on Publication Record