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@article{918900, author = {Mikulková, Zuzana and Praksová, Petra and Štourač, Pavel and Bednařík, Josef and Michálek, Jaroslav}, article_location = {Netherlands}, article_number = {1-2}, doi = {http://dx.doi.org/10.1016/j.jns.2010.08.053}, keywords = {multiple sclerosis; T-cells; memory cells; cytokines; flow cytometry}, language = {eng}, issn = {0022-510X}, journal = {Journal of the neurological sciences}, title = {Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis}, volume = {300}, year = {2011} }
TY - JOUR ID - 918900 AU - Mikulková, Zuzana - Praksová, Petra - Štourač, Pavel - Bednařík, Josef - Michálek, Jaroslav PY - 2011 TI - Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis JF - Journal of the neurological sciences VL - 300 IS - 1-2 SP - 135-141 EP - 135-141 PB - Amsterdam : Elsevier SN - 0022510X KW - multiple sclerosis KW - T-cells KW - memory cells KW - cytokines KW - flow cytometry N2 - In the present study, T-lymphocyte populations and pro-inflammatory as well as suppressive cytokine profiles were evaluated in detail in previously untreated patients with relapsing-remitting multiple sclerosis (RRMS). CD4(+) and CD8(+) naive, central memory (Tcm), effector memory (Tem), terminal effector memory (Ttem), CD4(+) regulatory T-cells (Treg) and CD8(+) T-suppressor cells (Ts) were analysed using flow cytometry, and levels of ten plasma cytokines were determined using fluorescent bead-based immunoassay. We evaluated two groups of RRMS with minor (n=33) and major (n=25) clinical impairment and compared them with healthy controls (n=40) in order to detect any correlation between severity of MS clinical symptoms and immune disturbances. In conclusion, we demonstrate complex immune dysbalances in untreated MS patients. ER -
MIKULKOVÁ, Zuzana, Petra PRAKSOVÁ, Pavel ŠTOURAČ, Josef BEDNAŘÍK and Jaroslav MICHÁLEK. Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis. \textit{Journal of the neurological sciences}. Netherlands: Amsterdam : Elsevier, 2011, vol.~300, 1-2, p.~135-141. ISSN~0022-510X. Available from: https://dx.doi.org/10.1016/j.jns.2010.08.053.
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