MIKULKOVÁ, Zuzana, Petra PRAKSOVÁ, Pavel ŠTOURAČ, Josef BEDNAŘÍK and Jaroslav MICHÁLEK. Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis. Journal of the neurological sciences. Netherlands: Amsterdam : Elsevier, 2011, vol. 300, 1-2, p. 135-141. ISSN 0022-510X. Available from: https://dx.doi.org/10.1016/j.jns.2010.08.053.
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Basic information
Original name Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis
Authors MIKULKOVÁ, Zuzana (203 Czech Republic, belonging to the institution), Petra PRAKSOVÁ (203 Czech Republic), Pavel ŠTOURAČ (203 Czech Republic), Josef BEDNAŘÍK (203 Czech Republic) and Jaroslav MICHÁLEK (203 Czech Republic, guarantor, belonging to the institution).
Edition Journal of the neurological sciences, Netherlands, Amsterdam : Elsevier, 2011, 0022-510X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.353
RIV identification code RIV/00216224:14740/11:00051674
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1016/j.jns.2010.08.053
UT WoS 000286850900025
Keywords (in Czech) roztroušená skleróza; T lymfocyty; paměťové buňky; cytokiny; průtoková cytometrie
Keywords in English multiple sclerosis; T-cells; memory cells; cytokines; flow cytometry
Tags ok, rivok
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 1/4/2012 14:19.
Abstract
In the present study, T-lymphocyte populations and pro-inflammatory as well as suppressive cytokine profiles were evaluated in detail in previously untreated patients with relapsing-remitting multiple sclerosis (RRMS). CD4(+) and CD8(+) naive, central memory (Tcm), effector memory (Tem), terminal effector memory (Ttem), CD4(+) regulatory T-cells (Treg) and CD8(+) T-suppressor cells (Ts) were analysed using flow cytometry, and levels of ten plasma cytokines were determined using fluorescent bead-based immunoassay. We evaluated two groups of RRMS with minor (n=33) and major (n=25) clinical impairment and compared them with healthy controls (n=40) in order to detect any correlation between severity of MS clinical symptoms and immune disturbances. In conclusion, we demonstrate complex immune dysbalances in untreated MS patients.
Links
MSM0021622404, plan (intention)Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.
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