Imbalance in T-cell and cytokine profiles in patients with
relapsing-remitting multiple sclerosis

J 2011

Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis

MIKULKOVÁ, Zuzana; Petra PRAKSOVÁ; Pavel ŠTOURAČ; Josef BEDNAŘÍK; Jaroslav MICHÁLEK et. al.

Basic information

Original name

Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis

Authors

MIKULKOVÁ, Zuzana; Petra PRAKSOVÁ; Pavel ŠTOURAČ; Josef BEDNAŘÍK and Jaroslav MICHÁLEK

Edition

Journal of the neurological sciences, Netherlands, Amsterdam : Elsevier, 2011, 0022-510X

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Netherlands

Confidentiality degree

is not subject to a state or trade secret

Impact factor

Impact factor: 2.353

RIV identification code

RIV/00216224:14740/11:00051674

Organization unit

Central European Institute of Technology

DOI

https://doi.org/10.1016/j.jns.2010.08.053

UT WoS

000286850900025

Keywords (in Czech)

roztroušená skleróza; T lymfocyty; paměťové buňky; cytokiny; průtoková cytometrie

Keywords in English

multiple sclerosis; T-cells; memory cells; cytokines; flow cytometry

Abstract

In the original language

In the present study, T-lymphocyte populations and pro-inflammatory as well as suppressive cytokine profiles were evaluated in detail in previously untreated patients with relapsing-remitting multiple sclerosis (RRMS). CD4(+) and CD8(+) naive, central memory (Tcm), effector memory (Tem), terminal effector memory (Ttem), CD4(+) regulatory T-cells (Treg) and CD8(+) T-suppressor cells (Ts) were analysed using flow cytometry, and levels of ten plasma cytokines were determined using fluorescent bead-based immunoassay. We evaluated two groups of RRMS with minor (n=33) and major (n=25) clinical impairment and compared them with healthy controls (n=40) in order to detect any correlation between severity of MS clinical symptoms and immune disturbances. In conclusion, we demonstrate complex immune dysbalances in untreated MS patients.

Links

MSM0021622404, plan (intention)

Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.

Cite

MIKULKOVÁ, Zuzana; Petra PRAKSOVÁ; Pavel ŠTOURAČ; Josef BEDNAŘÍK and Jaroslav MICHÁLEK. Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis. Journal of the neurological sciences. Netherlands: Amsterdam : Elsevier, 2011, vol. 300, 1-2, p. 135-141. ISSN 0022-510X. Available from: https://doi.org/10.1016/j.jns.2010.08.053.

@article{918900,
   author = {Mikulková, Zuzana and Praksová, Petra and Štourač, Pavel and Bednařík, Josef and Michálek, Jaroslav},
   article_location = {Netherlands},
   article_number = {1-2},
   doi = {https://doi.org/10.1016/j.jns.2010.08.053},
   keywords = {multiple sclerosis; T-cells; memory cells; cytokines; flow cytometry},
   language = {eng},
   issn = {0022-510X},
   journal = {Journal of the neurological sciences},
   title = {Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis},
   volume = {300},
   year = {2011}
}

TY  - JOUR
ID  - 918900
AU  - Mikulková, Zuzana - Praksová, Petra - Štourač, Pavel - Bednařík, Josef - Michálek, Jaroslav
PY  - 2011
TI  - Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis
JF  - Journal of the neurological sciences
VL  - 300
IS  - 1-2
SP  - 135-141
EP  - 135-141
PB  - Amsterdam : Elsevier
SN  - 0022510X
KW  - multiple sclerosis
KW  - T-cells
KW  - memory cells
KW  - cytokines
KW  - flow cytometry
N2  - In the present study, T-lymphocyte populations and pro-inflammatory as well as suppressive cytokine profiles were evaluated in detail in previously untreated patients with relapsing-remitting multiple sclerosis (RRMS). CD4(+) and CD8(+) naive, central memory (Tcm), effector memory (Tem), terminal effector memory (Ttem), CD4(+) regulatory T-cells (Treg) and CD8(+) T-suppressor cells (Ts) were analysed using flow cytometry, and levels of ten plasma cytokines were determined using fluorescent bead-based immunoassay. We evaluated two groups of RRMS with minor (n=33) and major (n=25) clinical impairment and compared them with healthy controls (n=40) in order to detect any correlation between severity of MS clinical symptoms and immune disturbances. In conclusion, we demonstrate complex immune dysbalances in untreated MS patients.
ER  -

MIKULKOVÁ, Zuzana; Petra PRAKSOVÁ; Pavel ŠTOURAČ; Josef BEDNAŘÍK and Jaroslav MICHÁLEK. Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis. \textit{Journal of the neurological sciences}. Netherlands: Amsterdam : Elsevier, 2011, vol.~300, 1-2, p.~135-141. ISSN~0022-510X. Available from: https://doi.org/10.1016/j.jns.2010.08.053.

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