J 2010

The effect of cortical repetitive transcranial magnetic stimulation on cognitive event-related potentials recorded in the subthalamic nucleus.

BALÁŽ, Marek, Hana SROVNALOVÁ, Irena REKTOROVÁ and Ivan REKTOR

Basic information

Original name

The effect of cortical repetitive transcranial magnetic stimulation on cognitive event-related potentials recorded in the subthalamic nucleus.

Authors

BALÁŽ, Marek (703 Slovakia, guarantor, belonging to the institution), Hana SROVNALOVÁ (203 Czech Republic, belonging to the institution), Irena REKTOROVÁ (203 Czech Republic, belonging to the institution) and Ivan REKTOR (203 Czech Republic, belonging to the institution)

Edition

Experimental Brain Research, Springer Verlag, 2010, 0014-4819

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.296

RIV identification code

RIV/00216224:14110/10:00046774

Organization unit

Faculty of Medicine

UT WoS

000277712500008

Keywords in English

inferior frontal cortex; subthalamic nucleus; executive functions; ERP; P3; hyperdirect pathway
Změněno: 20/1/2011 16:20, prof. MUDr. Irena Rektorová, Ph.D.

Abstract

V originále

We studied whether the cognitive event-related potentials (ERP) in the subthalamic nucleus (STN) are modified by the modulation of the inferior frontal cortex (IFC) and the dorsolateral prefrontal cortex (DLPFC) with repetitive transcranial magnetic stimulation (rTMS). Eighteen patients with Parkinson disease who had been implanted with a deep brain stimulation (DBS) electrode were included in the study. The ERPs were recorded from the DBS electrode before and after the rTMS (1 Hz, 600 pulses) over either the right IFC (10 patients) or right DLPFC (8 patients). rTMS over the right IFC led to a shortening of ERP latencies from 277 ms (SD) to 252 ms in the standard protocol and from 296 ms to 270 ms in the protocol modified by a higher load of executive functions. Connections (the IFC-STN hyperdirect pathway) with the cortex that bypass the BG-thalamocortical circuitries could explain the position of the STN in the processing of executive functions.

Links

MSM0021622404, plan (intention)
Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.