ACE gene insertion/deletion polymorphism has a moderate
influence on the acute development of left ventricular
dysfunction in patients with ST elevation myocardial infarction
treated with primary PCI

J 2010

ACE gene insertion/deletion polymorphism has a moderate influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI

PAŘENICA, Jiří, Monika PÁVKOVÁ GOLDBERGOVÁ, Petr KALA, Martin POLOCZEK, Jan MAŇOUŠEK et. al.

Basic information

Original name

ACE gene insertion/deletion polymorphism has a moderate influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI

Authors

PAŘENICA, Jiří (203 Czech Republic, guarantor, belonging to the institution), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Czech Republic, belonging to the institution), Petr KALA (203 Czech Republic, belonging to the institution), Martin POLOCZEK (203 Czech Republic, belonging to the institution), Jan MAŇOUŠEK (203 Czech Republic, belonging to the institution), Krystyna PRYMUSOVÁ (203 Czech Republic, belonging to the institution), Lenka KUBKOVÁ (203 Czech Republic, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), D. TOMČÍKOVÁ (203 Czech Republic), Ondřej TOMAN (203 Czech Republic, belonging to the institution), Martin TESÁK (203 Czech Republic, belonging to the institution), Josef TOMANDL (203 Czech Republic, belonging to the institution), Anna VAŠKŮ (203 Czech Republic, belonging to the institution) and Jindřich ŠPINAR (203 Czech Republic, belonging to the institution)

Edition

BMC Cardiovascular Disorders, BioMed Centrak ltd. 2010, 1471-2261

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.021

RIV identification code

RIV/00216224:14110/10:00040848

Organization unit

Faculty of Medicine

UT WoS

000286195500001

Keywords in English

ACE; polymorphism; gene; myocardial infarction

Změněno: 20/1/2011 12:18, doc. RNDr. Josef Tomandl, Ph.D.

Abstract

V originále

We evaluated the associations among angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism, ACE activity and post-myocardial infarction left ventricular dysfunction and acute heart failure early after presentation with MI with ST-segment elevation. A total of 556 patients with STEMI treated by primary PCI were the study population. The DD/ID genotypes were associated with a significantly higher risk of EF. These results suggest that the I/D polymorphism of ACE is associated with the development of LV dysfunction in the acute phase after STEMI. We demonstrated for the first time an association of the low ACE activity with the severe LV dysfunction, although patients with moderate LV dysfunction had higher level ACE activity than patients with preserved LV function.

Links

NS9880, research and development project

Name: Komplexní managment péče o pacienty as akutním srdečním selháním, jejichstřednědobá prognóza a multivariantní prognostický model

Investor: Ministry of Health of the CR

Citovat

PAŘENICA, Jiří, Monika PÁVKOVÁ GOLDBERGOVÁ, Petr KALA, Martin POLOCZEK, Jan MAŇOUŠEK, Krystyna PRYMUSOVÁ, Lenka KUBKOVÁ, Jiří JARKOVSKÝ, D. TOMČÍKOVÁ, Ondřej TOMAN, Martin TESÁK, Josef TOMANDL, Anna VAŠKŮ and Jindřich ŠPINAR. ACE gene insertion/deletion polymorphism has a moderate influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI. BMC Cardiovascular Disorders. BioMed Centrak ltd., 2010, vol. 10, No 60, 8 pp. ISSN 1471-2261.

@article{919825,
   author = {Pařenica, Jiří and Pávková Goldbergová, Monika and Kala, Petr and Poloczek, Martin and Maňoušek, Jan and Prymusová, Krystyna and Kubková, Lenka and Jarkovský, Jiří and Tomčíková, D. and Toman, Ondřej and Tesák, Martin and Tomandl, Josef and Vašků, Anna and Špinar, Jindřich},
   article_number = {60},
   keywords = {ACE; polymorphism; gene; myocardial infarction},
   language = {eng},
   issn = {1471-2261},
   journal = {BMC Cardiovascular Disorders},
   title = {ACE gene insertion/deletion polymorphism has a moderate influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI},
   volume = {10},
   year = {2010}
}

TY  - JOUR
ID  - 919825
AU  - Pařenica, Jiří - Pávková Goldbergová, Monika - Kala, Petr - Poloczek, Martin - Maňoušek, Jan - Prymusová, Krystyna - Kubková, Lenka - Jarkovský, Jiří - Tomčíková, D. - Toman, Ondřej - Tesák, Martin - Tomandl, Josef - Vašků, Anna - Špinar, Jindřich
PY  - 2010
TI  - ACE gene insertion/deletion polymorphism has a moderate influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI
JF  - BMC Cardiovascular Disorders
VL  - 10
IS  - 60
PB  - BioMed Centrak ltd.
SN  - 14712261
KW  - ACE
KW  - polymorphism
KW  - gene
KW  - myocardial infarction
N2  - We evaluated the associations among angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism, ACE activity and post-myocardial infarction left ventricular dysfunction and acute heart failure early after presentation with MI with ST-segment elevation. A total of 556 patients with STEMI treated by primary PCI were the study population. The DD/ID genotypes were associated with a significantly higher risk of EF. These results suggest that the I/D polymorphism of ACE is associated with the development of LV dysfunction in the acute phase after STEMI. We demonstrated for the first time an association of the low ACE activity with the severe LV dysfunction, although patients with moderate LV dysfunction had higher level ACE activity than patients with preserved LV function.
ER  -

PAŘENICA, Jiří, Monika PÁVKOVÁ GOLDBERGOVÁ, Petr KALA, Martin POLOCZEK, Jan MAŇOUŠEK, Krystyna PRYMUSOVÁ, Lenka KUBKOVÁ, Jiří JARKOVSKÝ, D. TOMČÍKOVÁ, Ondřej TOMAN, Martin TESÁK, Josef TOMANDL, Anna VAŠKŮ and Jindřich ŠPINAR. ACE gene insertion/deletion polymorphism has a moderate influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI. \textit{BMC Cardiovascular Disorders}. BioMed Centrak ltd., 2010, vol.~10, No~60, 8 pp. ISSN~1471-2261.

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