PACKWOOD, K., E. DREWE, E. STAPLES, D. WEBSTER, E. WITTE, J. LITZMAN, W. EGNER, R. SARGUR, W. SEWELL, E. LOPEZ-GRANADOS, S.L. SENEVIRATNE, R.J. POWELL, B.L. FERRY and H.M. CHAPEL. NOD2 polymorphisms in clinical phenotypes of common variable immunodeficiency disorders. Clin Exp Immunol. Blaskwell Synergy, 2010, vol. 161, No 3, p. 536-541. ISSN 0009-9104. |
Other formats:
BibTeX
LaTeX
RIS
@article{920489, author = {Packwood, K. and Drewe, E. and Staples, E. and Webster, D. and Witte, E. and Litzman, J. and Egner, W. and Sargur, R. and Sewell, W. and LopezandGranados, E. and Seneviratne, S.L. and Powell, R.J. and Ferry, B.L. and Chapel, H.M.}, article_number = {3}, keywords = {antibody deficiency; common variable immunodeficiency; disease susceptibility/resistance/polymorphisms; immunodeficiency-primary; immunogenetics}, language = {eng}, issn = {0009-9104}, journal = {Clin Exp Immunol}, title = {NOD2 polymorphisms in clinical phenotypes of common variable immunodeficiency disorders.}, volume = {161}, year = {2010} }
TY - JOUR ID - 920489 AU - Packwood, K. - Drewe, E. - Staples, E. - Webster, D. - Witte, E. - Litzman, J. - Egner, W. - Sargur, R. - Sewell, W. - Lopez-Granados, E. - Seneviratne, S.L. - Powell, R.J. - Ferry, B.L. - Chapel, H.M. PY - 2010 TI - NOD2 polymorphisms in clinical phenotypes of common variable immunodeficiency disorders. JF - Clin Exp Immunol VL - 161 IS - 3 SP - 536-541 EP - 536-541 PB - Blaskwell Synergy SN - 00099104 KW - antibody deficiency KW - common variable immunodeficiency KW - disease susceptibility/resistance/polymorphisms KW - immunodeficiency-primary KW - immunogenetics N2 - We present the frequencies of the different phenotypes of patients with CVID within our international cohort. Arg702trp polymorphisms were significantly less frequent than wild type (WT) (P=0,038) among international CVID patients with splenomegaly. Gly908arg polymorphisms were more prevalent than WT in UK patients with autoimmune disorders (P=0,049) or enteropathy (P=0,049). NOD2 polymorphisms were not more prevalent than WT in CVID patients with clinical phenotypes of granulomata. UK allele frequencies of 0,014, 0,056 and 0,026 were found for gly908arg, arg702trp and leu1007finsc NOD2 polymorphisms, respectively. These do not differ significantly from UK immunocompetent controls confirming, as expected, that in addition these NOD2 polymorphisms do not confer susceptibility to CVIDs per se. ER -
PACKWOOD, K., E. DREWE, E. STAPLES, D. WEBSTER, E. WITTE, J. LITZMAN, W. EGNER, R. SARGUR, W. SEWELL, E. LOPEZ-GRANADOS, S.L. SENEVIRATNE, R.J. POWELL, B.L. FERRY and H.M. CHAPEL. NOD2 polymorphisms in clinical phenotypes of common variable immunodeficiency disorders. \textit{Clin Exp Immunol}. Blaskwell Synergy, 2010, vol.~161, No~3, p.~536-541. ISSN~0009-9104.
|