J 2010

Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy

PÁCAL, Lukáš, Josef TOMANDL, Jan SVOJANOVSKÝ and Darja KRUSOVÁ

Basic information

Original name

Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy

Authors

PÁCAL, Lukáš (203 Czech Republic, guarantor, belonging to the institution), Josef TOMANDL (203 Czech Republic, belonging to the institution), Jan SVOJANOVSKÝ (203 Czech Republic, belonging to the institution) and Darja KRUSOVÁ (203 Czech Republic, belonging to the institution)

Edition

Nephrol Dial Transplant, Oxford, Oxford University Press, 2010, 1460-2385

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.564

RIV identification code

RIV/00216224:14110/10:00046873

Organization unit

Faculty of Medicine

UT WoS

000289309400018

Keywords in English

diabetic nephropathy. pentose phosphate pathway. thiamine. thiamine deficiency. transketolase
Změněno: 17/1/2011 15:02, doc. MUDr. Helena Němcová, CSc.

Abstract

V originále

Pentose phosphate pathway (PPP) represents a potentially protective mechanism in hyperglycaemia due to shunting of glycolytic intermediates into PPP reactions. We hypothesized that thiamine status (plasma and erythrocyte levels of thiamine and its esters) together with genetic variability in key PPP enzymes transketolase (TKT), transaldolase and TKT-like might contribute to the progression of diabetic nephropathy (DN) and mortality of diabetics.