PÁCAL, Lukáš, Josef TOMANDL, Jan SVOJANOVSKÝ and Darja KRUSOVÁ. Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy. Nephrol Dial Transplant. Oxford: Oxford University Press, 2010, vol. 2010, No 9, 8 pp. ISSN 1460-2385.
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Basic information
Original name Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy
Authors PÁCAL, Lukáš (203 Czech Republic, guarantor, belonging to the institution), Josef TOMANDL (203 Czech Republic, belonging to the institution), Jan SVOJANOVSKÝ (203 Czech Republic, belonging to the institution) and Darja KRUSOVÁ (203 Czech Republic, belonging to the institution).
Edition Nephrol Dial Transplant, Oxford, Oxford University Press, 2010, 1460-2385.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.564
RIV identification code RIV/00216224:14110/10:00046873
Organization unit Faculty of Medicine
UT WoS 000289309400018
Keywords in English diabetic nephropathy. pentose phosphate pathway. thiamine. thiamine deficiency. transketolase
Changed by Changed by: doc. MUDr. Helena Němcová, CSc., učo 659. Changed: 17/1/2011 15:02.
Abstract
Pentose phosphate pathway (PPP) represents a potentially protective mechanism in hyperglycaemia due to shunting of glycolytic intermediates into PPP reactions. We hypothesized that thiamine status (plasma and erythrocyte levels of thiamine and its esters) together with genetic variability in key PPP enzymes transketolase (TKT), transaldolase and TKT-like might contribute to the progression of diabetic nephropathy (DN) and mortality of diabetics.
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