Trends of primary and subsequent cancers of gastrointestinal tract in the Czech population, 1976-2005.

DÍTĚ, Petr and Edvard GERYK. Trends of primary and subsequent cancers of gastrointestinal tract in the Czech population, 1976-2005. Digestive Diseases. 2010, vol. 28, 4-5, p. 657-669. ISSN 0257-2753. Available from: https://dx.doi.org/10.1159/000320086.

Basic information

• Original name: Trends of primary and subsequent cancers of gastrointestinal tract in the Czech population, 1976-2005.
• Name in Czech: Vývoj primárních a následných nádorů trávicího traktu u české populace, 1976-2005.
• Authors: DÍTĚ, Petr (203 Czech Republic, guarantor, belonging to the institution) and Edvard GERYK (203 Czech Republic, belonging to the institution).
• Edition: Digestive Diseases, 2010, 0257-2753.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: Switzerland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 1.000
• RIV identification code: RIV/00216224:14110/10:00051732
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1159/000320086
• UT WoS: 000284551200016
• Keywords in English: gastrointestinal cancers;incidence; prevalence; primary and subsequent cancer; synchronous and metachronous occurrence; time and space distribution; clinical stages
• Tags: International impact

Abstract

A total of 355,624 new GI cancers registered in 1976-2005 in the Czech Cancer Registry there were 14,744 (4.1%) primary and 26,790 (7.5%) subsequent cases, of which were all GI multiple cancers in 12.1% males and 11.1% females. The primary GI cancers were followed by 16,362 other neoplasms (60.7% males, 39.3% females); the subsequent GI cancers were preceded by 31,519 other neoplasms (55.8% males, 44.2% females). Double neoplasms were higher in females, multiple cases in males. The number of primary cases peaked in 1997, the number of subsequent cases increased to 2005. Almost half of the cases were registered in the age group of 50-69 years. The average interval between primary GI cancers and subsequent neoplasms was 6.1 years; the ratio of synchronous to metachronous cases was 1:3.6 in males, 1:5 in females. The most frequent synchronous cases in males were cancers of other GI, urinary, genital and respiratory tract; in females these were cancers of other GI, genital and urinary tract and the breast. The most frequent cancers preceding the next subsequent GI cancer included primary cancers of the skin, other GI, genital, urinary and respiratory tract of males; those of the skin, genital and other GI tract and breast cancer of females. The 23,462 subsequent GI cancers reported as a second cancer included early stages in 29.6% males and 27.9% females, advanced stages in 31.2% males and 31.3% females, unknown stages in 39.3% males and 40.8% females. Of 3,562 primary neoplasms of only advanced stages before subsequent GI cancers were 2,093 cases at stage III (51.4% males, 48.6% females) and 1,469 cases at stage IV (60.2% males, 39.8% females); the most frequent in males were primary cancers of other GI, respiratory and genital tract, in females cancers of other GI, breast and genital cancers. Of 9,568 primary neoplasms before subsequent GI cancers only at advantage stages 3,325 cases were registered before stage III (53.9% males, 46.1% females) and 6,243 cases before stage IV (57.7% males, 42.3% females); the most frequent in males were primary cancers of skin, other GI, genital and urinary tract, those of skin, genital cancers, breast and other GI tract in females. Up to Oct. 2007, of the primary GI cancers 78.2% males died and 21.8% survived and those 76.6% females died and 23.4% survived; of the subsequent GI cancers 86.7% males died and 13.3% survived and those 85.7% females died and 14.3% survived.