Enhancement of retinoid-induced cell differentiation in cancer therapy.

VESELSKÁ, Renata, Martina RÉDOVÁ, Petr CHLAPEK, Karel ZITTERBART, Markéta HERMANOVÁ and Jaroslav ŠTĚRBA. Enhancement of retinoid-induced cell differentiation in cancer therapy. In International Journal of Mol. Medicine 26 (Sup. 1) - the 15th World Congress on Advances in Oncology and the 13th International Symposium on Molecular Medicine. 2010. ISSN 1107-3756.

Basic information

• Original name: Enhancement of retinoid-induced cell differentiation in cancer therapy.
• Name in Czech: Zesilování buněčné diferenciace indukované retinoidy v rámci protinádorové léčby.
• Authors: VESELSKÁ, Renata, Martina RÉDOVÁ, Petr CHLAPEK, Karel ZITTERBART, Markéta HERMANOVÁ and Jaroslav ŠTĚRBA.
• Edition: International Journal of Mol. Medicine 26 (Sup. 1) - the 15th World Congress on Advances in Oncology and the 13th International Symposium on Molecular Medicine. 2010.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 1.814
• Organization unit: Faculty of Science
• ISSN: 1107-3756
• UT WoS: 000283203400135
• Keywords in English: retinoids; ATRA; cell differentiation; pediatric tumors; caffeic acid; celecoxib
• Tags: International impact, Reviewed

Abstract

Retinoid-induced cell differentiation of transformed cells into mature phenotypes is one of the most promising strategies in recent antitumor therapy. This differentiation may be enhanced by inhibitors of enzymes that participate in the intracellular degradation pathway of retinoids, especially of lipoxygenases and cyclooxygenases.

Abstract (in Czech)

Buněčná diferenciace indukovaná retinoidy představuje jednu z nejslibnějších strategií v rámci současné protinádorové léčby. Tato indukovaná diferenciace může být dále zesílena pomocí inhibitorů enzymů, které participují v intracelulární degradaci retinoidů - zejména se jedná o inhibitory lipoxygenáz a cyklooxygenáz.

Links

• GD204/08/H054, research and development project: Name: Molekulární mechanismy proliferace a diferenciace buněk

Investor: Czech Science Foundation, Molecular mechanisms of the cell proliferation and differentiation

• MSM0021622415, plan (intention): Name: Molekulární podstata buněčných a tkáňových regulací

Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations

• NR9341, research and development project: Name: Modulace antineoplastického efektu retinoidů LOX/COX inhibitory na modelu dětských solidních nádorů: in vitro studie

Investor: Ministry of Health of the CR