| ŠTĚRBA, Jaroslav, Zdeněk PAVELKA, Nicolas ANDRÉ, Jiří VENTRUBA, Jarmila SKOTÁKOVÁ, Viera BAJČIOVÁ, Danica BRONIŠOVÁ, Lenka DUBSKÁ and Dalibor VALÍK. Second complete remission of relapsed medulloblastoma induced by metronomic chemotherapy. Pediatric Blood Cancer. USA: WILEY-LISS, DIV JOHN WILEY & SONS, 2010, vol. 54, No 4, p. 616-617. ISSN 1545-5009. Available from: https://dx.doi.org/10.1002/pbc.22382. |
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@article{921269,
author = {Štěrba, Jaroslav and Pavelka, Zdeněk and André, Nicolas and Ventruba, Jiří and Skotáková, Jarmila and Bajčiová, Viera and Bronišová, Danica and Dubská, Lenka and Valík, Dalibor},
article_location = {USA},
article_number = {4},
doi = {http://dx.doi.org/10.1002/pbc.22382},
keywords = {metronomic chemotherapy; relapsed medulloblastoma},
language = {eng},
issn = {1545-5009},
journal = {Pediatric Blood Cancer},
title = {Second complete remission of relapsed medulloblastoma induced by metronomic chemotherapy.},
volume = {54},
year = {2010}
}
TY - JOUR
ID - 921269
AU - Štěrba, Jaroslav - Pavelka, Zdeněk - André, Nicolas - Ventruba, Jiří - Skotáková, Jarmila - Bajčiová, Viera - Bronišová, Danica - Dubská, Lenka - Valík, Dalibor
PY - 2010
TI - Second complete remission of relapsed medulloblastoma induced by metronomic chemotherapy.
JF - Pediatric Blood Cancer
VL - 54
IS - 4
SP - 616-617
EP - 616-617
PB - WILEY-LISS, DIV JOHN WILEY & SONS
SN - 15455009
KW - metronomic chemotherapy
KW - relapsed medulloblastoma
N2 - Prognosis for children with relapsed medulloblastoma remains poor. Metronomic chemotherapy may offer some benefit to patients treated initially with intensive regimens. However, dosing and duration of such palliative treatment have not been systematically studied. Here we describe a child with medulloblastoma relapsing after initial high-dose chemotherapy and standard radiotherapy. The patient was then treated with metronomic chemotherapy and achieved second complete remission after 21 months of treatment. Three months off therapy he relapsed again and died from progressive disease. This case illustrates the potential benefit of metronomic chemotherapy but also shows the uncertainty of when to stop metronomic chemotherapy while balancing toxicity.
ER -
ŠTĚRBA, Jaroslav, Zdeněk PAVELKA, Nicolas ANDRÉ, Jiří VENTRUBA, Jarmila SKOTÁKOVÁ, Viera BAJČIOVÁ, Danica BRONIŠOVÁ, Lenka DUBSKÁ and Dalibor VALÍK. Second complete remission of relapsed medulloblastoma induced by metronomic chemotherapy. \textit{Pediatric Blood Cancer}. USA: WILEY-LISS, DIV JOHN WILEY \&{} SONS, 2010, vol.~54, No~4, p.~616-617. ISSN~1545-5009. Available from: https://dx.doi.org/10.1002/pbc.22382.
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