OHLÍDALOVÁ, Dana, Michal PÁSEK, Jiří ŠIMURDA and Georges CHRISTÉ. Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte. Analysis of Biomedical Signals and Images. Brno: VUTIUM Press, 2010, vol. 20, No 1, p. 114-117. ISSN 1211-412X.
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Basic information
Original name Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte
Name in Czech Fyziologické důsledky iontově-koncentračních změn v transverzálně-axiálním tubulárním systému v modelu lidské srdeční komorové buňky
Authors OHLÍDALOVÁ, Dana (203 Czech Republic), Michal PÁSEK (203 Czech Republic, guarantor), Jiří ŠIMURDA (203 Czech Republic, belonging to the institution) and Georges CHRISTÉ (250 France).
Edition Analysis of Biomedical Signals and Images, Brno, VUTIUM Press, 2010, 1211-412X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10610 Biophysics
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/10:00051747
Organization unit Faculty of Medicine
Keywords in English cardiac cell; transverse-axial tubular system; quantitative model
Tags accumulation-depletion of ions, Cardiac cell
Changed by Changed by: Mgr. Michal Petr, učo 65024. Changed: 10/4/2012 08:05.
Abstract
A mathematical model of human ventricular cell incorporating the transverse axial tubular system (TATS) was designed and used to explore the role of TATS in human ventricular cell electrophysiological activity. The model is based on the latest quantitative description of guinea pig ventricular cell electrophysiology and modified to respect the published data obtained from human cardiac preparations. Computer simulations suggest that significant transient depletions of Ca2+ ions and accumulation of K+ ions may occur in the human TATS. The preliminary analysis of the effects of tubular Ca2+depletions on the activity of the model cell indicates their role in limitation of intracellular Ca2+ overload at higher frequencies of stimulation.
Links
MSM0021622402, plan (intention)Name: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases
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