MMP-13 polymorphism (rs640198) in patients with confirmed CAD

VAŠKŮ, Anna, Jiří BLAHÁK, Monika PÁVKOVÁ GOLDBERGOVÁ, Iva BARTOŇOVÁ, Vladimír KINCL and Jaroslav MELUZÍN. MMP-13 polymorphism (rs640198) in patients with confirmed CAD. In ISP a SHR 2010, Montreal, Kanada. 2011.

Basic information

• Original name: MMP-13 polymorphism (rs640198) in patients with confirmed CAD
• Name in Czech: Polymorfismus v genu pro MMP-13 (rs640198) u pacientlů s potvrzenou nemocí koronárních artérií
• Authors: VAŠKŮ, Anna, Jiří BLAHÁK, Monika PÁVKOVÁ GOLDBERGOVÁ, Iva BARTOŇOVÁ, Vladimír KINCL and Jaroslav MELUZÍN.
• Edition: ISP a SHR 2010, Montreal, Kanada, 2011.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30105 Physiology
• Country of publisher: Canada
• Confidentiality degree: is not subject to a state or trade secret
• Organization unit: Faculty of Medicine
• Keywords (in Czech): MMP-13 polymorfismus CAD
• Keywords in English: MMP-13 polymorphism CAD

Abstract

The genetic background that underlies the susceptibility, occurrence and severity of CAD is still poorly elucidated. MMP-13 was proposed as another possible candidate for the NO-mediated prevention of atherosclerosis. The study comprised 1071 consecutive patients, 734 men and 337 women, median age 48 years, with suspected or known CAD referred for coronary angiography. During the short-term hospitalization the patients underwent full cardiologic investigation (history, physical examination, electrocardiography, laboratory examination, coronary angiography, echocardiography in patients with unclear diagnosis). The study was approved by the institutional ethics committee; informed consent of all patients is archived. The intron G/T polymorphism (rs640198) in MMP-13 gene was detected by TaqMan SNP genotyping. A significant difference in the MMP-13 polymorphism was observed between patients with clinically manifest coronary artery diseases (CAD) compared to those without the disease (Pg =0. 06, Pa=0.02). As a result of the multivariate analysis, significant interaction between MMP-13 polymorphism and the total number of stenoses was observed when EF LV and HR had been included as dependent continuous variables (P=0.03, power test = 96%). In detail, the TT genotype of MMP-13 differs from GG and GT genotypes whose EF LV gradually drops with higher number of stenoses. The values of heart rate are more oscillating in patients with the TT genotype. The TT genotype of MMP-13 polymorphism is associated with different hemodynamic characteristics compared to the other genotypes of the polymorphism in patients with coronary artery disease.

Abstract (in Czech)

Prokázali jsme signifikantní asociaci mezi alelou T polymorfismu rs604198 a počtem postižených tepen u pacientů s koronarograficky verifikovanou CAD.