Effects of redox conditions and zinc(II) ions on metallothionein aggregation revealed by chip capillary electrophoresis.

KŘÍŽKOVÁ, Soňa, Michal MASAŘÍK, Tomáš ECKSCHLAGER, Vojtěch ADAM and René KIZEK. Effects of redox conditions and zinc(II) ions on metallothionein aggregation revealed by chip capillary electrophoresis. Journal of Chromatography A. Amsterdam: Elsevier, 2010, vol. 1217, No 51, p. 7966-7971. ISSN 0021-9673.

Basic information

• Original name: Effects of redox conditions and zinc(II) ions on metallothionein aggregation revealed by chip capillary electrophoresis.
• Authors: KŘÍŽKOVÁ, Soňa (203 Czech Republic, belonging to the institution), Michal MASAŘÍK (203 Czech Republic, guarantor), Tomáš ECKSCHLAGER (203 Czech Republic), Vojtěch ADAM (203 Czech Republic, belonging to the institution) and René KIZEK (203 Czech Republic, belonging to the institution).
• Edition: Journal of Chromatography A, Amsterdam, Elsevier, 2010, 0021-9673.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10406 Analytical chemistry
• Country of publisher: Netherlands
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 4.194
• RIV identification code: RIV/00216224:14110/10:00040656
• Organization unit: Faculty of Medicine
• UT WoS: 000285429700006
• Keywords in English: Metallothionein; Chip capillary electrophoresis; Zinc; Redox conditions; Aggregation

Abstract

In this study we used capillary electrophoresis on chip coupled with fluorescence detection to determine structural changes of MT with increasing concentration of zinc(II) ions and under various redox conditions.

Abstract (in Czech)

Práce popisuje analýzu vlivu redoxních podmínek a zinku na agregaci metalothioneinu pomocí čipové kapilární elektroforézy.

Links

• GAP301/10/0356, research and development project: Name: Studie participace specifických mechanismů poškození DNA na cytoxicitě cytostatik vůči lidským chemosensitivním a chemorestentním neuroblastomům
• GP301/09/P436, research and development project: Name: Analýza metalothioneinu u karcinomu prostaty na úrovni DNA, RNA a proteinu.

Investor: Czech Science Foundation

• IAA401990701, research and development project: Name: Studium vazby platinových cytostatik do struktury DNA; Vliv metalothioneinu
• NS10200, research and development project: Name: Nádorové markery, jejich stanovení a korelace s karcinomem prostaty

Investor: Ministry of Health of the CR