J 2010

Relation between TGF-beta1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus. Relation between TGF-ß1 levels in cerebrospinal fluid and ETV outcome

LIPINA, Radim, Štefan REGULI, Ludmila NOVÁČKOVÁ, Hana PODEŠVOVÁ, Eva BRICHTOVÁ et. al.

Basic information

Original name

Relation between TGF-beta1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus. Relation between TGF-ß1 levels in cerebrospinal fluid and ETV outcome

Authors

LIPINA, Radim (203 Czech Republic, guarantor), Štefan REGULI (203 Czech Republic), Ludmila NOVÁČKOVÁ (203 Czech Republic), Hana PODEŠVOVÁ (203 Czech Republic) and Eva BRICHTOVÁ (203 Czech Republic, belonging to the institution)

Edition

Childs Nerv Syst, 2010, 0256-7040

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.314

RIV identification code

RIV/00216224:14110/10:00047019

Organization unit

Faculty of Medicine

UT WoS

000274500800009

Keywords in English

Posthemorrhagic hydrocephalus Endoscopic third ventriculostomy Transforming growth factor beta1 Premature infants
Změněno: 27/2/2011 20:13, prof. MUDr. Eva Brichtová, Ph.D.

Abstract

V originále

Though pathophysiology of PHH is more complicated and TGF-beta1 is not the only one to play a role in it, we have documented in our study that TGF-beta1 level in CSF collected in the beginning of temporary treatment of PHH correlates with failure of CSF resorption. In our study, in 62.5% of patients with proof of obstruction, hyporesorptive component was present. Overall, ETV success rate in therapy of obstructive PHH 37.5% in our study. We have proven that premature newborns with lower TGF-beta1 level and proof of obstructive HDC on MRI have significantly higer success rate of endoscopic treatment. In our study, ETV success rate was 100% in this group. Our results show that TGF-beta1 may influence succes rate of ETV in treatment of PHH, and based on its levels, it is possible to choose patients with purely obstructive hydrocephalus.