Relation between TGF-beta1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus. Relation between TGF-ß1 levels in cerebrospinal fluid and ETV outcome

LIPINA, Radim, Štefan REGULI, Ludmila NOVÁČKOVÁ, Hana PODEŠVOVÁ and Eva BRICHTOVÁ. Relation between TGF-beta1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus. Relation between TGF-ß1 levels in cerebrospinal fluid and ETV outcome. Childs Nerv Syst. 2010, vol. 26, No 3, p. 333-341. ISSN 0256-7040.

Basic information

• Original name: Relation between TGF-beta1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus. Relation between TGF-ß1 levels in cerebrospinal fluid and ETV outcome
• Authors: LIPINA, Radim (203 Czech Republic, guarantor), Štefan REGULI (203 Czech Republic), Ludmila NOVÁČKOVÁ (203 Czech Republic), Hana PODEŠVOVÁ (203 Czech Republic) and Eva BRICHTOVÁ (203 Czech Republic, belonging to the institution).
• Edition: Childs Nerv Syst, 2010, 0256-7040.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 1.314
• RIV identification code: RIV/00216224:14110/10:00047019
• Organization unit: Faculty of Medicine
• UT WoS: 000274500800009
• Keywords in English: Posthemorrhagic hydrocephalus Endoscopic third ventriculostomy Transforming growth factor beta1 Premature infants

Abstract

Though pathophysiology of PHH is more complicated and TGF-beta1 is not the only one to play a role in it, we have documented in our study that TGF-beta1 level in CSF collected in the beginning of temporary treatment of PHH correlates with failure of CSF resorption. In our study, in 62.5% of patients with proof of obstruction, hyporesorptive component was present. Overall, ETV success rate in therapy of obstructive PHH 37.5% in our study. We have proven that premature newborns with lower TGF-beta1 level and proof of obstructive HDC on MRI have significantly higer success rate of endoscopic treatment. In our study, ETV success rate was 100% in this group. Our results show that TGF-beta1 may influence succes rate of ETV in treatment of PHH, and based on its levels, it is possible to choose patients with purely obstructive hydrocephalus.