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@article{921868,
author = {Zítka, Ondřej and Kukačka, Jiří and Křížková, Soňa and Húska, Dalibor and Adam, Vojtěch and Masařík, Michal and Průša, Richard and Kizek, René},
article_number = {31},
keywords = {matrix metalloproteinases; collagen; tissue inhibitors of matrix metalloproteinases; cysteine switch; zinc; metallothionein; tumour disease},
language = {eng},
issn = {0929-8673},
journal = {Current Medicinal Chemistry},
title = {Matrix metalloproteinases.},
volume = {17},
year = {2010}
}
TY - JOUR
ID - 921868
AU - Zítka, Ondřej - Kukačka, Jiří - Křížková, Soňa - Húska, Dalibor - Adam, Vojtěch - Masařík, Michal - Průša, Richard - Kizek, René
PY - 2010
TI - Matrix metalloproteinases.
JF - Current Medicinal Chemistry
VL - 17
IS - 31
SN - 09298673
KW - matrix metalloproteinases
KW - collagen
KW - tissue inhibitors of matrix metalloproteinases
KW - cysteine switch
KW - zinc
KW - metallothionein
KW - tumour disease
N2 - Matrix metalloproteinases (MMPs), also known as matrixins, belong to a group of zinc-dependent proteins, which are thought to play a central role in the breakdown of extracellular matrix. Collagen, elastin, gelatine and casein are major components cleaved by MMPs. The breakdown of these components is essential for many physiological processes such as embryonic development, morphogenesis, reproduction, and tissue resorption and remodelling. MMPs also participate in pathological processes such as arthritis, cancer, cardiovascular and neurological diseases. This review summarizes current knowledge regarding these proteins, their participation in physiological and pathophysiological roles, their involvement in activation and inhibition, and their interactions with other metal-binding proteins including metallothioneins.
ER -
ZÍTKA, Ondřej, Jiří KUKAČKA, Soňa KŘÍŽKOVÁ, Dalibor HÚSKA, Vojtěch ADAM, Michal MASAŘÍK, Richard PRŮŠA and René KIZEK. Matrix metalloproteinases. \textit{Current Medicinal Chemistry}. 2010, vol.~17, No~31, 18 pp. ISSN~0929-8673.
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