J 2011

Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: An unexpected prognostic significance?

KŘEN, Leoš, Ondřej SLABÝ, Katarína MÚČKOVÁ, Eva LŽIČAŘOVÁ, Marek SOVA et. al.

Basic information

Original name

Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: An unexpected prognostic significance?

Authors

KŘEN, Leoš (203 Czech Republic, guarantor, belonging to the institution), Ondřej SLABÝ (203 Czech Republic, belonging to the institution), Katarína MÚČKOVÁ (703 Slovakia, belonging to the institution), Eva LŽIČAŘOVÁ (203 Czech Republic, belonging to the institution), Marek SOVA (203 Czech Republic), Václav VYBÍHAL (203 Czech Republic, belonging to the institution), Tomáš SVOBODA (203 Czech Republic, belonging to the institution), Pavel FADRUS (203 Czech Republic, belonging to the institution), Radek LAKOMÝ (203 Czech Republic, belonging to the institution), Petr VAŇHARA (203 Czech Republic, belonging to the institution), Zdenka KŘENOVÁ (203 Czech Republic, belonging to the institution), Jaroslav ŠTĚRBA (203 Czech Republic, belonging to the institution), Martin SMRČKA (203 Czech Republic, belonging to the institution) and Jaroslav MICHÁLEK (203 Czech Republic, belonging to the institution)

Edition

Neuropathology, 2011, 0919-6544

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.022

RIV identification code

RIV/00216224:14110/11:00051771

Organization unit

Faculty of Medicine

DOI

UT WoS

000288547400004

Keywords in English

glioblastoma; HLA-E; HLA-G; survival

Tags

International impact
Změněno: 1/8/2013 10:52, Ing. Mgr. Věra Pospíšilíková

Abstract

V originále

The role of nonclassical human leukocyte antigens G and E (HLA-G and HLA-E) was originally thought to be restricted to the protection of the fetus from a maternal allorecognition. Now it is known that HLA-G and HLA-E exert multiple immunoregulatory functions. A prognostic significance of the expression of HLA-G and HLA-E by neoplastic cells in glioblastoma is not well characterized. In this study, we evaluated the expression of HLA-G and HLA-E by neoplastic cells in 39 cases of glioblastoma. We found the production of HLA-G and HLA in a majority of cases. There was an unexpected positive correlation between the expression of HLA-E and length of survival. We speculate that the expression of this molecule by neoplastic cells may represent a coincidental selective pro-host advantage related to better response to subsequent therapeutic modalities. Mechanisms of glioblastoma cell pathophysiology and mechanisms of responses to therapeutic interventions in respect to the expression of these molecules deserves further study.