The asociation of diabetic nephropathy, progression and mortality to functional pentose cycle deficiency as a result of abnormal metabolism od thiamine in DM

KRUSOVÁ, Darja, Lukáš PÁCAL, Kateřina KAŇKOVÁ, Josef TOMANDL, Veronika TANHÄUSEROVÁ and Jindřich OLŠOVSKÝ. The asociation of diabetic nephropathy, progression and mortality to functional pentose cycle deficiency as a result of abnormal metabolism od thiamine in DM. 2010. ISSN 1420-4096.

Basic information

• Original name: The asociation of diabetic nephropathy, progression and mortality to functional pentose cycle deficiency as a result of abnormal metabolism od thiamine in DM
• Name (in English): The asociation of diabetic nephropathy, progression and mortality to functional pentose cycle deficiency as a result of abnormal metabolism od thiamine in DM
• Authors: KRUSOVÁ, Darja, Lukáš PÁCAL, Kateřina KAŇKOVÁ, Josef TOMANDL, Veronika TANHÄUSEROVÁ and Jindřich OLŠOVSKÝ.
• Edition: 2010.

Other information

• Original language: Czech
• Type of outcome: Conference abstract
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 1.500
• Organization unit: Faculty of Medicine
• ISSN: 1420-4096
• Keywords (in Czech): thiamin; pentózový cyklus; Diabetická nefropatie
• Keywords in English: diabetic nephropathy; thiamin; pentose phoshate cycle

Abstract

The results support the role of functional thiamine deficiency in the development of hyperglycaemia- related pathology. Limited intracellular availability of active TKT co-factor seems to be a dominant abnormality.

Abstract (in English)

The results support the role of functional thiamine deficiency in the development of hyperglycaemia- related pathology. Limited intracellular availability of active TKT co-factor seems to be a dominant abnormality.

Links

• NR9443, research and development project: Name: Genetická variabilita enzymů pentózového cyklu jako faktor modulující nástup a progresi diabetické nefropatie

Investor: Ministry of Health of the CR, Genetic variability of pentose phosphate pathway as a modulating factor of the onset and progression of diabetic nephropathy