| DWYER, Michael, Kamil PARUCH, Marc LABROLI, Carmen ALVAREZ, Kerry KEERTIKAR, Cory POKER, Randall ROSSMAN, Thierry FISCHMANN, Jose DUCA, Vincent MADISON, David PARRY, Nicole DAVIS, Wolfgang SEGHEZZI, Derek WISWELL and Timothy GUZI. Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1. Bioorganic & Medicinal Chemistry Letters. Elsevier, 2011, vol. 21, No 1, p. 467-470. ISSN 0960-894X. |
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@article{923150,
author = {Dwyer, Michael and Paruch, Kamil and Labroli, Marc and Alvarez, Carmen and Keertikar, Kerry and Poker, Cory and Rossman, Randall and Fischmann, Thierry and Duca, Jose and Madison, Vincent and Parry, David and Davis, Nicole and Seghezzi, Wolfgang and Wiswell, Derek and Guzi, Timothy},
article_number = {1},
keywords = {Kinase CHK1 Pyrazolo[1 5-a]pyrimidine Template},
language = {eng},
issn = {0960-894X},
journal = {Bioorganic & Medicinal Chemistry Letters},
title = {Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1.},
volume = {21},
year = {2011}
}
TY - JOUR
ID - 923150
AU - Dwyer, Michael - Paruch, Kamil - Labroli, Marc - Alvarez, Carmen - Keertikar, Kerry - Poker, Cory - Rossman, Randall - Fischmann, Thierry - Duca, Jose - Madison, Vincent - Parry, David - Davis, Nicole - Seghezzi, Wolfgang - Wiswell, Derek - Guzi, Timothy
PY - 2011
TI - Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1.
JF - Bioorganic & Medicinal Chemistry Letters
VL - 21
IS - 1
SP - 467-470
EP - 467-470
PB - Elsevier
SN - 0960894X
KW - Kinase CHK1 Pyrazolo[1 5-a]pyrimidine Template
N2 - The synthesis and hit-to-lead SAR development of a pyrazolo[1,5-a]pyrimidine hit 4 is described leading to a series of potent, selective CHK1 inhibitors such as compound 17r. In the Letter, the further utility of the pyrazolo[1,5-a]pyrimidine template for the development of potent, selective kinase inhibitors is detailed.
ER -
DWYER, Michael, Kamil PARUCH, Marc LABROLI, Carmen ALVAREZ, Kerry KEERTIKAR, Cory POKER, Randall ROSSMAN, Thierry FISCHMANN, Jose DUCA, Vincent MADISON, David PARRY, Nicole DAVIS, Wolfgang SEGHEZZI, Derek WISWELL and Timothy GUZI. Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1. \textit{Bioorganic \&{} Medicinal Chemistry Letters}. Elsevier, 2011, vol.~21, No~1, p.~467-470. ISSN~0960-894X.
|
