| FURBERG, Helena, Yun Lung KIM, J. DACKOR, E. BOERWINKLE, N. FRANCESCHINI, D. ARDISSINO, L. BERNARDINELLI, P. MANNUCCI, F. MAURI, P. MERLINI, D. ABSHER, T. ASSIMES, S. FORTMANN, C. IRIBARREN, J. KNOWLES, T. QUERTERMOUS, L. FERRUCCI, T. TANAKA, J. BIS, C. FURBERG, T. HARITUNIANS, B. MCKNIGHT, B. PSATY, K. TAYLOR, E. THACKER, P. ALMGREN, L. GROOP, C. LADENVALL, M. BOEHNKE, A. JACKSON, K. MOHLKE, H. STRINGHAM, J. TUOMILEHTO, E. BENJAMIN, S. HWANG, D. LEVY, S. PREIS, R. VASAN, J. DUAN, P. GEJMAN, D. LEVINSON, A. SANDERS, J. SHI, E. LIPS, J. MCKAY, A. AGUDO, L. BARZAN, V. BENCKO, S. BENHAMOU, X. CASTELLSAGUE, C. CANOVA, D. CONWAY, E. FABIANOVA, Lenka FORETOVÁ, V. JANOUT, C. HEALY, I. HOLCATOVA, K. KJAERHEIM, P. LAGIOU, J. LISSOWSKA, R. LOWRY, T. MACFARLANE, D. MATES, L. RICHIARDI, P. RUDNAI, N. SZESZENIA-DABROWSKA, D. ZARIDZE, A. ZNAOR, M. LATHROP, P. BRENNAN, S. BANDINELLI, T. FRAYLING, J. GURALNIK, Y. MILANESCHI, J. PERRY, D. ALTSHULER, R. ELOSUA, S. KATHIRESAN, G. LUCAS, O. MELANDER, Ch. O'DONNELL, V. SALOMAA, S. SCHWARTZ, B. VOIGHT, B. PENNINX, J. SMIT, J. VOGELZANGS, D. BOOMSMA, E.J.C. DE GEUS, J. VINK, G. WILLEMSEN, S. CHANOCK, F. GU, S. HANKINSON, D. HUNTER, A. HOFMAN, H. TIEMEIER, G. PARE, P. RIDKER, M. LI, H. MAES, J. AUDRAIN-MCGOVERN, D. POSTHUMA, L. THORNTON, C. LERMAN, J. KAPRIO, J. ROSE, J. IOANNIDIS, P. KRAFT, D. LIN, P. SULLIVAN, B.M. EVERETT, D. CHASMAN, S. WALTER, C. VAN DUIJN a A.D. UITTERLINDEN. Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nature genetics. New York: Nature Publishing Group, 2010, roč. 42, č. 5, s. 441-447. ISSN 1061-4036. Dostupné z: https://dx.doi.org/10.1038/ng.571. |
Další formáty:
BibTeX
LaTeX
RIS
@article{923430,
author = {Furberg, Helena and Kim, Yun Lung and Dackor, J. and Boerwinkle, E. and Franceschini, N. and Ardissino, D. and Bernardinelli, L. and Mannucci, P. and Mauri, F. and Merlini, P. and Absher, D. and Assimes, T. and Fortmann, S. and Iribarren, C. and Knowles, J. and Quertermous, T. and Ferrucci, L. and Tanaka, T. and Bis, J. and Furberg, C. and Haritunians, T. and McKnight, B. and Psaty, B. and Taylor, K. and Thacker, E. and Almgren, P. and Groop, L. and Ladenvall, C. and Boehnke, M. and Jackson, A. and Mohlke, K. and Stringham, H. and Tuomilehto, J. and Benjamin, E. and Hwang, S. and Levy, D. and Preis, S. and Vasan, R. and Duan, J. and Gejman, P. and Levinson, D. and Sanders, A. and Shi, J. and Lips, E. and Mckay, J. and Agudo, A. and Barzan, L. and Bencko, V. and Benhamou, S. and Castellsague, X. and Canova, C. and Conway, D. and Fabianova, E. and Foretová, Lenka and Janout, V. and Healy, C. and Holcatova, I. and Kjaerheim, K. and Lagiou, P. and Lissowska, J. and Lowry, R. and Macfarlane, T. and Mates, D. and Richiardi, L. and Rudnai, P. and SzeszeniaandDabrowska, N. and Zaridze, D. and Znaor, A. and Lathrop, M. and Brennan, P. and Bandinelli, S. and Frayling, T. and Guralnik, J. and Milaneschi, Y. and Perry, J. and Altshuler, D. and Elosua, R. and Kathiresan, S. and Lucas, G. and Melander, O. and O'Donnell, Ch. and Salomaa, V. and Schwartz, S. and Voight, B. and Penninx, B. and Smit, J. and Vogelzangs, J. and Boomsma, D. and de Geus, E.J.C. and Vink, J. and Willemsen, G. and Chanock, S. and Gu, F. and Hankinson, S. and Hunter, D. and Hofman, A. and Tiemeier, H. and Pare, G. and Ridker, P. and Li, M. and Maes, H. and AudrainandMcGovern, J. and Posthuma, D. and Thornton, L. and Lerman, C. and Kaprio, J. and Rose, J. and Ioannidis, J. and Kraft, P. and Lin, D. and Sullivan, P. and Everett, B.M. and Chasman, D. and Walter, S. and van Duijn, C. and Uitterlinden, A.D.},
article_location = {New York},
article_number = {5},
doi = {http://dx.doi.org/10.1038/ng.571},
keywords = {NICOTINE DEPENDENCE; ENVIRONMENTAL-FACTORS; IMPUTATION; GENES; VARIANTS; DISEASES; SETS},
language = {eng},
issn = {1061-4036},
journal = {Nature genetics},
title = {Genome-wide meta-analyses identify multiple loci associated with smoking behavior},
volume = {42},
year = {2010}
}
TY - JOUR
ID - 923430
AU - Furberg, Helena - Kim, Yun Lung - Dackor, J. - Boerwinkle, E. - Franceschini, N. - Ardissino, D. - Bernardinelli, L. - Mannucci, P. - Mauri, F. - Merlini, P. - Absher, D. - Assimes, T. - Fortmann, S. - Iribarren, C. - Knowles, J. - Quertermous, T. - Ferrucci, L. - Tanaka, T. - Bis, J. - Furberg, C. - Haritunians, T. - McKnight, B. - Psaty, B. - Taylor, K. - Thacker, E. - Almgren, P. - Groop, L. - Ladenvall, C. - Boehnke, M. - Jackson, A. - Mohlke, K. - Stringham, H. - Tuomilehto, J. - Benjamin, E. - Hwang, S. - Levy, D. - Preis, S. - Vasan, R. - Duan, J. - Gejman, P. - Levinson, D. - Sanders, A. - Shi, J. - Lips, E. - Mckay, J. - Agudo, A. - Barzan, L. - Bencko, V. - Benhamou, S. - Castellsague, X. - Canova, C. - Conway, D. - Fabianova, E. - Foretová, Lenka - Janout, V. - Healy, C. - Holcatova, I. - Kjaerheim, K. - Lagiou, P. - Lissowska, J. - Lowry, R. - Macfarlane, T. - Mates, D. - Richiardi, L. - Rudnai, P. - Szeszenia-Dabrowska, N. - Zaridze, D. - Znaor, A. - Lathrop, M. - Brennan, P. - Bandinelli, S. - Frayling, T. - Guralnik, J. - Milaneschi, Y. - Perry, J. - Altshuler, D. - Elosua, R. - Kathiresan, S. - Lucas, G. - Melander, O. - O'Donnell, Ch. - Salomaa, V. - Schwartz, S. - Voight, B. - Penninx, B. - Smit, J. - Vogelzangs, J. - Boomsma, D. - de Geus, E.J.C. - Vink, J. - Willemsen, G. - Chanock, S. - Gu, F. - Hankinson, S. - Hunter, D. - Hofman, A. - Tiemeier, H. - Pare, G. - Ridker, P. - Li, M. - Maes, H. - Audrain-McGovern, J. - Posthuma, D. - Thornton, L. - Lerman, C. - Kaprio, J. - Rose, J. - Ioannidis, J. - Kraft, P. - Lin, D. - Sullivan, P. - Everett, B.M. - Chasman, D. - Walter, S. - van Duijn, C. - Uitterlinden, A.D.
PY - 2010
TI - Genome-wide meta-analyses identify multiple loci associated with smoking behavior
JF - Nature genetics
VL - 42
IS - 5
SP - 441-447
EP - 441-447
PB - Nature Publishing Group
SN - 10614036
KW - NICOTINE DEPENDENCE
KW - ENVIRONMENTAL-FACTORS
KW - IMPUTATION
KW - GENES
KW - VARIANTS
KW - DISEASES
KW - SETS
N2 - Consistent but indirect evidence has implicated genetic factors in smoking behavior1,2. We report meta-analyses of several smoking phenotypes within cohorts of the Tobacco and Genetics Consortium (n = 74,053). We also partnered with the European Network of Genetic and Genomic Epidemiology (ENGAGE) and Oxford-GlaxoSmithKline (Ox-GSK) consortia to follow up the 15 most significant regions (n > 140,000). We identified three loci associated with number of cigarettes smoked per day. The strongest association was a synonymous 15q25 SNP in the nicotinic receptor gene CHRNA3 (rs1051730[A], b = 1.03, standard error (s.e.) = 0.053, beta = 2.8 x 10(-73)). Two 10q25 SNPs (rs1329650[G], b = 0.367, s. e. = 0.059, beta = 5.7 x 10(-10); and rs1028936[A], b = 0.446, s. e. = 0.074, beta = 1.3 x 10(-9)) and one 9q13 SNP in EGLN2 (rs3733829[G], b = 0.333, s. e. = 0.058, P = 1.0 x 10(-8)) also exceeded genome-wide significance for cigarettes per day. For smoking initiation, eight SNPs exceeded genome-wide significance, with the strongest association at a nonsynonymous SNP in BDNF on chromosome 11 (rs6265[C], odds ratio (OR) = 1.06, 95% confidence interval (Cl) 1.04-1.08, P = 1.8 x 10(-8)). One SNP located near DBH on chromosome 9 (rs3025343[G], OR = 1.12, 95% Cl 1.08-1.18, P = 3.6 x 10(-8)) was significantly associated with smoking cessation.
ER -
FURBERG, Helena, Yun Lung KIM, J. DACKOR, E. BOERWINKLE, N. FRANCESCHINI, D. ARDISSINO, L. BERNARDINELLI, P. MANNUCCI, F. MAURI, P. MERLINI, D. ABSHER, T. ASSIMES, S. FORTMANN, C. IRIBARREN, J. KNOWLES, T. QUERTERMOUS, L. FERRUCCI, T. TANAKA, J. BIS, C. FURBERG, T. HARITUNIANS, B. MCKNIGHT, B. PSATY, K. TAYLOR, E. THACKER, P. ALMGREN, L. GROOP, C. LADENVALL, M. BOEHNKE, A. JACKSON, K. MOHLKE, H. STRINGHAM, J. TUOMILEHTO, E. BENJAMIN, S. HWANG, D. LEVY, S. PREIS, R. VASAN, J. DUAN, P. GEJMAN, D. LEVINSON, A. SANDERS, J. SHI, E. LIPS, J. MCKAY, A. AGUDO, L. BARZAN, V. BENCKO, S. BENHAMOU, X. CASTELLSAGUE, C. CANOVA, D. CONWAY, E. FABIANOVA, Lenka FORETOVÁ, V. JANOUT, C. HEALY, I. HOLCATOVA, K. KJAERHEIM, P. LAGIOU, J. LISSOWSKA, R. LOWRY, T. MACFARLANE, D. MATES, L. RICHIARDI, P. RUDNAI, N. SZESZENIA-DABROWSKA, D. ZARIDZE, A. ZNAOR, M. LATHROP, P. BRENNAN, S. BANDINELLI, T. FRAYLING, J. GURALNIK, Y. MILANESCHI, J. PERRY, D. ALTSHULER, R. ELOSUA, S. KATHIRESAN, G. LUCAS, O. MELANDER, Ch. O'DONNELL, V. SALOMAA, S. SCHWARTZ, B. VOIGHT, B. PENNINX, J. SMIT, J. VOGELZANGS, D. BOOMSMA, E.J.C. DE GEUS, J. VINK, G. WILLEMSEN, S. CHANOCK, F. GU, S. HANKINSON, D. HUNTER, A. HOFMAN, H. TIEMEIER, G. PARE, P. RIDKER, M. LI, H. MAES, J. AUDRAIN-MCGOVERN, D. POSTHUMA, L. THORNTON, C. LERMAN, J. KAPRIO, J. ROSE, J. IOANNIDIS, P. KRAFT, D. LIN, P. SULLIVAN, B.M. EVERETT, D. CHASMAN, S. WALTER, C. VAN DUIJN a A.D. UITTERLINDEN. Genome-wide meta-analyses identify multiple loci associated with smoking behavior. \textit{Nature genetics}. New York: Nature Publishing Group, 2010, roč.~42, č.~5, s.~441-447. ISSN~1061-4036. Dostupné z: https://dx.doi.org/10.1038/ng.571.
|
