NEČAS, Alois, Ladislav PLÁNKA, Robert SRNEC, Michal CRHA, Jana HLUČILOVÁ, Jiří KLÍMA, David STARÝ, Leoš KŘEN, Evžen AMLER, Lucy VOJTOVÁ, Josef JANČÁŘ and Petr GÁL. Quality of Newly Formed Cartilaginous Tissue in Defects of Articular Surface after Transplantation of Mesenchymal Stem Cells in a Composite Scaffold Based on Collagen I with Chitosan Micro- and Nanofibres. Physiol. Res. Praha: Akademi věd ČR, 2010, vol. 59, No 4, p. 605-614. ISSN 0862-8408.
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Basic information
Original name Quality of Newly Formed Cartilaginous Tissue in Defects of Articular Surface after Transplantation of Mesenchymal Stem Cells in a Composite Scaffold Based on Collagen I with Chitosan Micro- and Nanofibres
Name in Czech Kvalita nově vzniklé chrupavčité tkáně v defektu kloubního povrchu po transplantaci MSCs a kompozitního nosiče na základě kolagenu I a chitosanových mikro a nanovláken.
Authors NEČAS, Alois (203 Czech Republic, guarantor, belonging to the institution), Ladislav PLÁNKA (203 Czech Republic, belonging to the institution), Robert SRNEC (203 Czech Republic), Michal CRHA (203 Czech Republic, belonging to the institution), Jana HLUČILOVÁ (203 Czech Republic), Jiří KLÍMA (203 Czech Republic), David STARÝ (203 Czech Republic, belonging to the institution), Leoš KŘEN (203 Czech Republic, belonging to the institution), Evžen AMLER (203 Czech Republic, belonging to the institution), Lucy VOJTOVÁ (203 Czech Republic, belonging to the institution), Josef JANČÁŘ (203 Czech Republic, belonging to the institution) and Petr GÁL (203 Czech Republic, belonging to the institution).
Edition Physiol. Res. Praha, Akademi věd ČR, 2010, 0862-8408.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30211 Orthopaedics
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.646
RIV identification code RIV/00216224:14110/10:00047141
Organization unit Faculty of Medicine
UT WoS 000282054700015
Keywords in English bone marrow mesenchymal stem cells;allogeneic;micropicking;articular cartilage
Changed by Changed by: prof. MUDr. Ladislav Plánka, Ph.D., učo 20583. Changed: 17/3/2011 02:07.
Abstract
It follows from the above-said that treatment of iatrogenic lesions of the surface of articular cartilage on femur condyles in miniature pigs after transplantation of mesenchymal stem cells in a composite scaffold based on collagen I containing micro- and nanofibers from chitosan resulted in filling of tissue defects in a hyaline type of cartilage. Lesions treated by implantation of scaffold alone or by micropicking were filled with fibrous cartilage with inferior macroscopic, histological and immunohistochemical parameters.
Links
2B06130, research and development projectName: Využití nově syntetizovaných biomateriálů v kombinaci s kmenovými buňkami v léčbě chorob, které postihují lidské tkáně derivované z mesodermu: chrupavku, kost, vazy a menisky. (Acronym: Chondros)
Investor: Ministry of Education, Youth and Sports of the CR
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