Quality of Newly Formed Cartilaginous Tissue in Defects of
Articular Surface after Transplantation of Mesenchymal Stem
Cells in a Composite Scaffold Based on Collagen I with Chitosan
Micro- and Nanofibres

J 2010

Quality of Newly Formed Cartilaginous Tissue in Defects of Articular Surface after Transplantation of Mesenchymal Stem Cells in a Composite Scaffold Based on Collagen I with Chitosan Micro- and Nanofibres

NEČAS, Alois, Ladislav PLÁNKA, Robert SRNEC, Michal CRHA, Jana HLUČILOVÁ et. al.

Basic information

Original name

Quality of Newly Formed Cartilaginous Tissue in Defects of Articular Surface after Transplantation of Mesenchymal Stem Cells in a Composite Scaffold Based on Collagen I with Chitosan Micro- and Nanofibres

Name in Czech

Kvalita nově vzniklé chrupavčité tkáně v defektu kloubního povrchu po transplantaci MSCs a kompozitního nosiče na základě kolagenu I a chitosanových mikro a nanovláken.

Authors

NEČAS, Alois (203 Czech Republic, guarantor, belonging to the institution), Ladislav PLÁNKA (203 Czech Republic, belonging to the institution), Robert SRNEC (203 Czech Republic), Michal CRHA (203 Czech Republic, belonging to the institution), Jana HLUČILOVÁ (203 Czech Republic), Jiří KLÍMA (203 Czech Republic), David STARÝ (203 Czech Republic, belonging to the institution), Leoš KŘEN (203 Czech Republic, belonging to the institution), Evžen AMLER (203 Czech Republic, belonging to the institution), Lucy VOJTOVÁ (203 Czech Republic, belonging to the institution), Josef JANČÁŘ (203 Czech Republic, belonging to the institution) and Petr GÁL (203 Czech Republic, belonging to the institution)

Edition

Physiol. Res. Praha, Akademi věd ČR, 2010, 0862-8408

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30211 Orthopaedics

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.646

RIV identification code

RIV/00216224:14110/10:00047141

Organization unit

Faculty of Medicine

UT WoS

000282054700015

Keywords in English

bone marrow mesenchymal stem cells;allogeneic;micropicking;articular cartilage

Změněno: 17/3/2011 02:07, prof. MUDr. Ladislav Plánka, Ph.D.

Abstract

V originále

It follows from the above-said that treatment of iatrogenic lesions of the surface of articular cartilage on femur condyles in miniature pigs after transplantation of mesenchymal stem cells in a composite scaffold based on collagen I containing micro- and nanofibers from chitosan resulted in filling of tissue defects in a hyaline type of cartilage. Lesions treated by implantation of scaffold alone or by micropicking were filled with fibrous cartilage with inferior macroscopic, histological and immunohistochemical parameters.

Links

2B06130, research and development project

Name: Využití nově syntetizovaných biomateriálů v kombinaci s kmenovými buňkami v léčbě chorob, které postihují lidské tkáně derivované z mesodermu: chrupavku, kost, vazy a menisky. (Acronym: Chondros)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

NEČAS, Alois, Ladislav PLÁNKA, Robert SRNEC, Michal CRHA, Jana HLUČILOVÁ, Jiří KLÍMA, David STARÝ, Leoš KŘEN, Evžen AMLER, Lucy VOJTOVÁ, Josef JANČÁŘ and Petr GÁL. Quality of Newly Formed Cartilaginous Tissue in Defects of Articular Surface after Transplantation of Mesenchymal Stem Cells in a Composite Scaffold Based on Collagen I with Chitosan Micro- and Nanofibres. Physiol. Res. Praha: Akademi věd ČR, 2010, vol. 59, No 4, p. 605-614. ISSN 0862-8408.

@article{923548,
   author = {Nečas, Alois and Plánka, Ladislav and Srnec, Robert and Crha, Michal and Hlučilová, Jana and Klíma, Jiří and Starý, David and Křen, Leoš and Amler, Evžen and Vojtová, Lucy and Jančář, Josef and Gál, Petr},
   article_location = {Praha},
   article_number = {4},
   keywords = {bone marrow mesenchymal stem cells;allogeneic;micropicking;articular cartilage},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiol. Res.},
   title = {Quality of Newly Formed Cartilaginous Tissue in Defects of Articular Surface after Transplantation of Mesenchymal Stem Cells in a Composite Scaffold Based on Collagen I with Chitosan Micro- and Nanofibres},
   volume = {59},
   year = {2010}
}

TY  - JOUR
ID  - 923548
AU  - Nečas, Alois - Plánka, Ladislav - Srnec, Robert - Crha, Michal - Hlučilová, Jana - Klíma, Jiří - Starý, David - Křen, Leoš - Amler, Evžen - Vojtová, Lucy - Jančář, Josef - Gál, Petr
PY  - 2010
TI  - Quality of Newly Formed Cartilaginous Tissue in Defects of Articular Surface after Transplantation of Mesenchymal Stem Cells in a Composite Scaffold Based on Collagen I with Chitosan Micro- and Nanofibres
JF  - Physiol. Res.
VL  - 59
IS  - 4
SP  - 605-614
EP  - 605-614
PB  - Akademi věd ČR
SN  - 08628408
KW  - bone marrow mesenchymal stem cells;allogeneic;micropicking;articular cartilage
N2  - It follows from the above-said that treatment of iatrogenic lesions of the surface of articular cartilage on femur condyles in miniature pigs after transplantation of mesenchymal stem cells in a composite scaffold based on collagen I containing micro- and nanofibers from chitosan resulted in filling of tissue defects in a hyaline type of cartilage. Lesions treated by implantation of scaffold alone or by micropicking were filled with fibrous cartilage with inferior macroscopic, histological and immunohistochemical parameters.
ER  -

NEČAS, Alois, Ladislav PLÁNKA, Robert SRNEC, Michal CRHA, Jana HLUČILOVÁ, Jiří KLÍMA, David STARÝ, Leoš KŘEN, Evžen AMLER, Lucy VOJTOVÁ, Josef JANČÁŘ and Petr GÁL. Quality of Newly Formed Cartilaginous Tissue in Defects of Articular Surface after Transplantation of Mesenchymal Stem Cells in a Composite Scaffold Based on Collagen I with Chitosan Micro- and Nanofibres. \textit{Physiol. Res.}. Praha: Akademi věd ČR, 2010, vol.~59, No~4, p.~605-614. ISSN~0862-8408.

Detailed Information on Publication Record