Detailed Information on Publication Record

ČEŠKOVÁ, Eva, Radovan PŘIKRYL and Tomáš KAŠPÁREK. Outcome in males with first-episode schizophrenia: 7-year follow-up. The World Journal of Biological Psychiatry. Oslo: Taylor and Francis, 2011, vol. 12, No 1, p. 66-72. ISSN 1562-2975. Available from: https://dx.doi.org/10.3109/15622975.2010.518625.

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Basic information
Original name	Outcome in males with first-episode schizophrenia: 7-year follow-up
Name in Czech	Výsledky u mužů s první epizodou schizofrenie: 7 let poté
Authors	ČEŠKOVÁ, Eva (203 Czech Republic, guarantor, belonging to the institution), Radovan PŘIKRYL (203 Czech Republic, belonging to the institution) and Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution).
Edition	The World Journal of Biological Psychiatry, Oslo, Taylor and Francis, 2011, 1562-2975.

Other information
Original language	English
Type of outcome	Article in a journal
Field of Study	30000 3. Medical and Health Sciences
Country of publisher	United Kingdom of Great Britain and Northern Ireland
Confidentiality degree	is not subject to a state or trade secret
Impact factor	Impact factor: 2.385
RIV identification code	RIV/00216224:14110/11:00051913
Organization unit	Faculty of Medicine
Doi	http://dx.doi.org/10.3109/15622975.2010.518625
UT WoS	000286900400006
Keywords (in Czech)	první epizoda schizofrenie; symptomy; dlouhodobé sledování; remise
Keywords in English	first episode schizophrenia; symptoms; long term follow up; remission
Tags	International impact
Changed by	Changed by: Mgr. Michal Petr, učo 65024. Changed: 12/4/2012 09:32.

Abstract
Objectives. The early course of schizophrenia is highly variable. We assessed outcomes of patients with first-episode schizophrenia at 7-year follow-up. Methods. Consecutively hospitalized male patients were included if they were experiencing their first admission for first-episode schizophrenia and were reassessed at 1-, 4- and 7-year follow-ups. The psychopathology was evaluated using the PANSS, relative decrease of PANSS and remission status based on severity of core symptoms. Results. Forty-four of 76 patients were reassessed three times. At the end of index hospitalization 73% of patients achieved remission; however, after 1, 4 and 7 years, the percentage had dropped to 50, 50 and 52%, respectively. When compared post-hoc there was no significant difference in PANSS and response to treatment between remitters and non-remitters during the index hospitalization; however, a significant difference in psychopathology emerged first after 1, 4 and 7 years. All patients who had not achieve remission after 1 year also failed to achieve remission after 4 and 7 years. Conclusions. Response to treatment during the first psychotic break-through may not be a decisive indicator for the outlook of the disease. Our data suggest that when deterioration occurs, it does so early after the first episode.

Abstract

Objectives. The early course of schizophrenia is highly variable. We assessed outcomes of patients with first-episode schizophrenia at 7-year follow-up. Methods. Consecutively hospitalized male patients were included if they were experiencing their first admission for first-episode schizophrenia and were reassessed at 1-, 4- and 7-year follow-ups. The psychopathology was evaluated using the PANSS, relative decrease of PANSS and remission status based on severity of core symptoms. Results. Forty-four of 76 patients were reassessed three times. At the end of index hospitalization 73% of patients achieved remission; however, after 1, 4 and 7 years, the percentage had dropped to 50, 50 and 52%, respectively. When compared post-hoc there was no significant difference in PANSS and response to treatment between remitters and non-remitters during the index hospitalization; however, a significant difference in psychopathology emerged first after 1, 4 and 7 years. All patients who had not achieve remission after 1 year also failed to achieve remission after 4 and 7 years. Conclusions. Response to treatment during the first psychotic break-through may not be a decisive indicator for the outlook of the disease. Our data suggest that when deterioration occurs, it does so early after the first episode.

Abstract (in Czech)
Odpověď na léčbu v průběhu prvních epizod schizofrenie nemusí být rozhodujícím ukazatelem pro další průběh nemoci. Naše data ukazují, že pokud ke zhoršení dojde, stává se to brzy po první epizodě.

Links
MSM0021622404, plan (intention)	Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
MSM0021622404, plan (intention)	Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.