HUDSON, J J R, Kateřina BEDNÁŘOVÁ, Lucie KOZÁKOVÁ, Chunyan LIAO, Marc GUÉRINEAU, Rita COLNAGHI, Susanne VIDOT, Jaromír MAREK, Sreenivas Reddy BATHULA, Alan LEHMANN and Jan PALEČEK. Interactions between the Nse3 and Nse4 Components of the SMC5-6 Complex Identify Evolutionarily Conserved Interactions between MAGE and EID Families. PloS ONE. San Francisco: Public Library of Science, 2011, vol. 6, No 2, p. "nestránkováno", 14 pp. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0017270.
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Basic information
Original name Interactions between the Nse3 and Nse4 Components of the SMC5-6 Complex Identify Evolutionarily Conserved Interactions between MAGE and EID Families
Name in Czech Interakce mezi Nse3 a Nse4 podjednotkami SMC5-6 komplexu ukazují na evoluční konzervaci vazby mezi MAGE a EID proteinovými rodinami
Authors HUDSON, J J R (826 United Kingdom of Great Britain and Northern Ireland), Kateřina BEDNÁŘOVÁ (203 Czech Republic, belonging to the institution), Lucie KOZÁKOVÁ (203 Czech Republic, belonging to the institution), Chunyan LIAO (826 United Kingdom of Great Britain and Northern Ireland), Marc GUÉRINEAU (250 France, belonging to the institution), Rita COLNAGHI (826 United Kingdom of Great Britain and Northern Ireland), Susanne VIDOT (826 United Kingdom of Great Britain and Northern Ireland), Jaromír MAREK (203 Czech Republic, belonging to the institution), Sreenivas Reddy BATHULA (356 India, belonging to the institution), Alan LEHMANN (826 United Kingdom of Great Britain and Northern Ireland) and Jan PALEČEK (203 Czech Republic, guarantor, belonging to the institution).
Edition PloS ONE, San Francisco, Public Library of Science, 2011, 1932-6203.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10600 1.6 Biological sciences
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 4.092
RIV identification code RIV/00216224:14740/11:00049415
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1371/journal.pone.0017270
UT WoS 000287764100039
Keywords in English SMC5-6 complex; Nse3/MAGE; Nse4/EID; genome stability; transcription regulation; evolution; placental mammals
Tags MAGE proteins, ok, rivok, SMC5-6 complex
Tags International impact, Reviewed
Changed by Changed by: doc. Mgr. Jan Paleček, Dr. rer. nat., učo 38623. Changed: 20/1/2017 11:39.
Abstract
The SMC5-6 protein complex is involved in the cellular response to DNA damage. It is composed of 6 - 8 polypeptides, of which Nse1, Nse3 and Nse4 form a tight sub-complex. MAGEG1, the mammalian ortholog of Nse3, is the founding member of the MAGE (melanoma-associated antigen) protein family and Nse4 is related to the EID (E1A-like inhibitor of differentiation) family of transcriptional repressors. We have identified a conserved hydrophobic surface on the C-terminal domain of Nse3 that interacts with Nse4 and identified residues in its N-terminal domain that are essential for interaction with Nse1. We show that these interactions are conserved in the human orthologs. In an examination of the evolutionary conservation of the Nse3-Nse4 interactions, we find that most MAGE proteins can interact with at least one of the NSE4/EID proteins.
Links
GD204/08/H054, research and development projectName: Molekulární mechanismy proliferace a diferenciace buněk
Investor: Czech Science Foundation, Molecular mechanisms of the cell proliferation and differentiation
IAA501630902, research and development projectName: Charakterizace MAGE proteinů: kofaktory E3 ubiquitin ligáz?
Investor: Academy of Sciences of the Czech Republic
MSM0021622415, plan (intention)Name: Molekulární podstata buněčných a tkáňových regulací
Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations
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