| ČERVENKA, Igor, Joshua WOLF, Jan MAŠEK, Pavel KREJČÍ, William R WILCOX, Alois KOZUBÍK, Gunnar SCHULTE, J Silvio GUTKIND and Vítězslav BRYJA. Mitogen-Activated Protein Kinases Promote WNT/beta-Catenin Signaling via Phosphorylation of LRP6. January 2011. Washington, D.C.: ASM, 2011, vol. 31, No 1, p. 179-189. ISSN 0270-7306. Available from: https://dx.doi.org/10.1128/MCB.00550-10. |
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@article{929220,
author = {Červenka, Igor and Wolf, Joshua and Mašek, Jan and Krejčí, Pavel and Wilcox, William R and Kozubík, Alois and Schulte, Gunnar and Gutkind, J Silvio and Bryja, Vítězslav},
article_location = {Washington, D.C.},
article_number = {1},
doi = {http://dx.doi.org/10.1128/MCB.00550-10},
keywords = {MAPK; mitogen kinases; beta-catenin; wnt; LRP6},
language = {eng},
issn = {0270-7306},
journal = {January 2011},
title = {Mitogen-Activated Protein Kinases Promote WNT/beta-Catenin Signaling via Phosphorylation of LRP6},
volume = {31},
year = {2011}
}
TY - JOUR
ID - 929220
AU - Červenka, Igor - Wolf, Joshua - Mašek, Jan - Krejčí, Pavel - Wilcox, William R - Kozubík, Alois - Schulte, Gunnar - Gutkind, J Silvio - Bryja, Vítězslav
PY - 2011
TI - Mitogen-Activated Protein Kinases Promote WNT/beta-Catenin Signaling via Phosphorylation of LRP6
JF - January 2011
VL - 31
IS - 1
SP - 179-189
EP - 179-189
PB - ASM
SN - 02707306
KW - MAPK
KW - mitogen kinases
KW - beta-catenin
KW - wnt
KW - LRP6
N2 - LDL-related protein 6 (LRP6) is a coreceptor of WNTs and a key regulator of the WNT/beta-catenin pathway. Upon activation LRP6 is phosphorylated within its intracellular PPPS/TP motifs. On the basis of a kinome-wide siRNA screen and confirmative biochemical analysis, we show that several proline-directed mitogen-activated protein kinases (MAPKs), such as p38, ERK1/2 and JNK1 are sufficient and required for the phosphorylation of PPPS/TP motifs of LRP6. External stimuli, which control the activity of MAPKs, such as phorbolesters and fibroblast growth factor 2 (FGF2) control the choice of the LRP6-PPPS/TP kinase and regulate the amplitude of LRP6 phosphorylation and WNT/beta-catenin-dependent transcription. Our findings suggest that cells recruit not only one dedicated LRP6 kinase but rather select their LRP6 kinase depending on cell type and the external stimulus.
ER -
ČERVENKA, Igor, Joshua WOLF, Jan MAŠEK, Pavel KREJČÍ, William R WILCOX, Alois KOZUBÍK, Gunnar SCHULTE, J Silvio GUTKIND and Vítězslav BRYJA. Mitogen-Activated Protein Kinases Promote WNT/beta-Catenin Signaling via Phosphorylation of LRP6. \textit{January 2011}. Washington, D.C.: ASM, 2011, vol.~31, No~1, p.~179-189. ISSN~0270-7306. Available from: https://dx.doi.org/10.1128/MCB.00550-10.
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