Other formats:
BibTeX
LaTeX
RIS
@proceedings{934408,
author = {Theopold, Ulrich and Wang, Zhi and Dobeš, Pavel and Hyršl, Pavel},
booktitle = {52nd Annual Drosophila Research Conference},
keywords = {Drosophila; Heterorhabditis; immunity; clotting; eicosanoids},
language = {eng},
title = {Hemolymph clotting and immunity.},
year = {2011}
}
TY - CONF
ID - 934408
AU - Theopold, Ulrich - Wang, Zhi - Dobeš, Pavel - Hyršl, Pavel
PY - 2011
TI - Hemolymph clotting and immunity.
KW - Drosophila
KW - Heterorhabditis
KW - immunity
KW - clotting
KW - eicosanoids
N2 - We are interested in the clotting of insect hemolymph. Clotting in Drosophila involves the precipitation of clotting factors and crosslinking of the clot. The latter process is mediated through the activity of the two enzymes transglutaminase and phenoloxidase. Our recent work shows that in addition to sealing wounds clotting also has a major function in protecting Drosophila larvae from infections. Larvae with reduced expression of either clotting factors or transglutaminase are more susceptible to infections with certain bacteria. The most significant effects were observed when we infected larvae using a natural infection model involving entomopathogenic nematodes and their associated bacteria. Our most recent results show that while single mutants in several previously characterized immune pathways (such as the imd pathway) behave similar to normal larvae, double mutants succumb faster to the infection. For example Bc/imd double mutants show immune defects. Using inhibitors of eicosanoid biosynthesis and knockdown lines specific for candidate genes involved in eicosanoid production we also provide evidence that lipid mediators might play a role in insect immunity. Finally, we also show that blood clots in mammals contribute to immunity.
ER -
THEOPOLD, Ulrich, Zhi WANG, Pavel DOBEŠ and Pavel HYRŠL. Hemolymph clotting and immunity. In \textit{52nd Annual Drosophila Research Conference}. 2011.
|
