Effect of perphenazine on electrogram of rat isolated heart

FIALOVÁ, Kateřina, Jiří BLAHÁK, Marek MOTOLA, Jiří JARKOVSKÝ, Jan MUŽÍK and Marie NOVÁKOVÁ. Effect of perphenazine on electrogram of rat isolated heart. Acta Veterinaria Brno. Brno, 2011, vol. 80, No 1, p. 87-92. ISSN 0001-7213. Available from: https://dx.doi.org/10.2754/avb201180010087.

Basic information

• Original name: Effect of perphenazine on electrogram of rat isolated heart
• Authors: FIALOVÁ, Kateřina (203 Czech Republic, guarantor, belonging to the institution), Jiří BLAHÁK (203 Czech Republic, belonging to the institution), Marek MOTOLA (703 Slovakia, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Jan MUŽÍK (203 Czech Republic, belonging to the institution) and Marie NOVÁKOVÁ (203 Czech Republic, belonging to the institution).
• Edition: Acta Veterinaria Brno, Brno, 2011, 0001-7213.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30105 Physiology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 0.431
• RIV identification code: RIV/00216224:14110/11:00049756
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.2754/avb201180010087
• UT WoS: 000289532200012
• Keywords (in Czech): Fenothiaziny; Langendorffovo srdce; QT-interval; Arytmie
• Keywords in English: Phenothiazines; Langendorff heart; QT-interval; Arrhythmia
• Tags: International impact

Abstract

The aim of this study was to clarify whether administration of antipsychotic perphenazine contributes to the electrophysiological changes of the isolated heart. Fourteen adult male Wistar rats were divided into two groups. Langendorff hearts were perfused with Krebs-Henseleit solution at constant pressure (85 mmHg). The electrogram was recorded by touch-free method. The hearts of the first group were exposed to 3.10-5 M perphenazine, the hearts of the second group to 3.10-8 M perphenazine. The incidence of arrhythmias and the heart rate and QT interval changes were studied on electrogram during 30 min periods of control, the first perphenazine administration, washout, and the second drug administration. Perphenazine administration significantly prolonged QT and QTc in group 1. In group 2, QT and QTc prolongation was less pronounced. A number of arrhythmias appeared, from single premature ventricular complexes to more severe ones in both groups. The heart rate changes were non-significant.

Links

• GA102/07/1473, research and development project: Name: Optické metody registrace elektrických potenciálů a koncentrace vápníku v srdci s laserovou stabilizací

Investor: Czech Science Foundation

• MSM0021622402, plan (intention): Name: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases