Effect of perphenazine on electrogram of rat isolated heart

J 2011

Effect of perphenazine on electrogram of rat isolated heart

FIALOVÁ, Kateřina, Jiří BLAHÁK, Marek MOTOLA, Jiří JARKOVSKÝ, Jan MUŽÍK et. al.

Basic information

Original name

Effect of perphenazine on electrogram of rat isolated heart

Authors

FIALOVÁ, Kateřina (203 Czech Republic, guarantor, belonging to the institution), Jiří BLAHÁK (203 Czech Republic, belonging to the institution), Marek MOTOLA (703 Slovakia, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Jan MUŽÍK (203 Czech Republic, belonging to the institution) and Marie NOVÁKOVÁ (203 Czech Republic, belonging to the institution)

Edition

Acta Veterinaria Brno, Brno, 2011, 0001-7213

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 0.431

RIV identification code

RIV/00216224:14110/11:00049756

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.2754/avb201180010087

UT WoS

000289532200012

Keywords (in Czech)

Fenothiaziny; Langendorffovo srdce; QT-interval; Arytmie

Keywords in English

Phenothiazines; Langendorff heart; QT-interval; Arrhythmia

Abstract

V originále

The aim of this study was to clarify whether administration of antipsychotic perphenazine contributes to the electrophysiological changes of the isolated heart. Fourteen adult male Wistar rats were divided into two groups. Langendorff hearts were perfused with Krebs-Henseleit solution at constant pressure (85 mmHg). The electrogram was recorded by touch-free method. The hearts of the first group were exposed to 3.10-5 M perphenazine, the hearts of the second group to 3.10-8 M perphenazine. The incidence of arrhythmias and the heart rate and QT interval changes were studied on electrogram during 30 min periods of control, the first perphenazine administration, washout, and the second drug administration. Perphenazine administration significantly prolonged QT and QTc in group 1. In group 2, QT and QTc prolongation was less pronounced. A number of arrhythmias appeared, from single premature ventricular complexes to more severe ones in both groups. The heart rate changes were non-significant.

Links

GA102/07/1473, research and development project

Name: Optické metody registrace elektrických potenciálů a koncentrace vápníku v srdci s laserovou stabilizací

Investor: Czech Science Foundation

MSM0021622402, plan (intention)

Name: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases

Citovat

FIALOVÁ, Kateřina, Jiří BLAHÁK, Marek MOTOLA, Jiří JARKOVSKÝ, Jan MUŽÍK and Marie NOVÁKOVÁ. Effect of perphenazine on electrogram of rat isolated heart. Acta Veterinaria Brno. Brno, 2011, vol. 80, No 1, p. 87-92. ISSN 0001-7213. Available from: https://dx.doi.org/10.2754/avb201180010087.

@article{934836,
   author = {Fialová, Kateřina and Blahák, Jiří and Motola, Marek and Jarkovský, Jiří and Mužík, Jan and Nováková, Marie},
   article_location = {Brno},
   article_number = {1},
   doi = {http://dx.doi.org/10.2754/avb201180010087},
   keywords = {Phenothiazines; Langendorff heart; QT-interval; Arrhythmia},
   language = {eng},
   issn = {0001-7213},
   journal = {Acta Veterinaria Brno},
   title = {Effect of perphenazine on electrogram of rat isolated heart},
   volume = {80},
   year = {2011}
}

TY  - JOUR
ID  - 934836
AU  - Fialová, Kateřina - Blahák, Jiří - Motola, Marek - Jarkovský, Jiří - Mužík, Jan - Nováková, Marie
PY  - 2011
TI  - Effect of perphenazine on electrogram of rat isolated heart
JF  - Acta Veterinaria Brno
VL  - 80
IS  - 1
SP  - 87-92
EP  - 87-92
SN  - 00017213
KW  - Phenothiazines
KW  - Langendorff heart
KW  - QT-interval
KW  - Arrhythmia
N2  - The aim of this study was to clarify whether administration of antipsychotic perphenazine contributes to the electrophysiological changes of the isolated heart. Fourteen adult male Wistar rats were divided into two groups. Langendorff hearts were perfused with Krebs-Henseleit solution at constant pressure (85 mmHg). The electrogram was recorded by touch-free method. The hearts of the first group were exposed to 3.10-5 M perphenazine, the hearts of the second group to 3.10-8 M perphenazine. The incidence of arrhythmias and the heart rate and QT interval changes were studied on electrogram during 30 min periods of control, the first perphenazine administration, washout, and the second drug administration. Perphenazine administration significantly prolonged QT and QTc in group 1. In group 2, QT and QTc prolongation was less pronounced. A number of arrhythmias appeared, from single premature ventricular complexes to more severe ones in both groups. The heart rate changes were non-significant.
ER  -

FIALOVÁ, Kateřina, Jiří BLAHÁK, Marek MOTOLA, Jiří JARKOVSKÝ, Jan MUŽÍK and Marie NOVÁKOVÁ. Effect of perphenazine on electrogram of rat isolated heart. \textit{Acta Veterinaria Brno}. Brno, 2011, vol.~80, No~1, p.~87-92. ISSN~0001-7213. Available from: https://dx.doi.org/10.2754/avb201180010087.

Detailed Information on Publication Record