| FIALOVÁ, Kateřina, Jiří BLAHÁK, Marek MOTOLA, Jiří JARKOVSKÝ, Jan MUŽÍK a Marie NOVÁKOVÁ. Effect of perphenazine on electrogram of rat isolated heart. Acta Veterinaria Brno. Brno, 2011, roč. 80, č. 1, s. 87-92. ISSN 0001-7213. Dostupné z: https://dx.doi.org/10.2754/avb201180010087. |
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@article{934836,
author = {Fialová, Kateřina and Blahák, Jiří and Motola, Marek and Jarkovský, Jiří and Mužík, Jan and Nováková, Marie},
article_location = {Brno},
article_number = {1},
doi = {http://dx.doi.org/10.2754/avb201180010087},
keywords = {Phenothiazines; Langendorff heart; QT-interval; Arrhythmia},
language = {eng},
issn = {0001-7213},
journal = {Acta Veterinaria Brno},
title = {Effect of perphenazine on electrogram of rat isolated heart},
volume = {80},
year = {2011}
}
TY - JOUR
ID - 934836
AU - Fialová, Kateřina - Blahák, Jiří - Motola, Marek - Jarkovský, Jiří - Mužík, Jan - Nováková, Marie
PY - 2011
TI - Effect of perphenazine on electrogram of rat isolated heart
JF - Acta Veterinaria Brno
VL - 80
IS - 1
SP - 87-92
EP - 87-92
SN - 00017213
KW - Phenothiazines
KW - Langendorff heart
KW - QT-interval
KW - Arrhythmia
N2 - The aim of this study was to clarify whether administration of antipsychotic perphenazine contributes to the electrophysiological changes of the isolated heart. Fourteen adult male Wistar rats were divided into two groups. Langendorff hearts were perfused with Krebs-Henseleit solution at constant pressure (85 mmHg). The electrogram was recorded by touch-free method. The hearts of the first group were exposed to 3.10-5 M perphenazine, the hearts of the second group to 3.10-8 M perphenazine. The incidence of arrhythmias and the heart rate and QT interval changes were studied on electrogram during 30 min periods of control, the first perphenazine administration, washout, and the second drug administration. Perphenazine administration significantly prolonged QT and QTc in group 1. In group 2, QT and QTc prolongation was less pronounced. A number of arrhythmias appeared, from single premature ventricular complexes to more severe ones in both groups. The heart rate changes were non-significant.
ER -
FIALOVÁ, Kateřina, Jiří BLAHÁK, Marek MOTOLA, Jiří JARKOVSKÝ, Jan MUŽÍK a Marie NOVÁKOVÁ. Effect of perphenazine on electrogram of rat isolated heart. \textit{Acta Veterinaria Brno}. Brno, 2011, roč.~80, č.~1, s.~87-92. ISSN~0001-7213. Dostupné z: https://dx.doi.org/10.2754/avb201180010087.
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