| BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Effect of Ajmaline on Action Potential and Ionic Currents in Rat Ventricular Myocytes with Focus on Transient Outward Current. In The 29th meeting of the European Working Group of Cardiac Cellular Electrophysiology, Antwerp (Belgium), 9. – 11. 9. 2005. 2005. |
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@proceedings{935639,
author = {Bébarová, Markéta and Matejovič, Peter and Pásek, Michal and Šimurdová, Milena and Šimurda, Jiří},
booktitle = {The 29th meeting of the European Working Group of Cardiac Cellular Electrophysiology, Antwerp (Belgium), 9. – 11. 9. 2005},
keywords = {ajmaline; ionic current; transient outward potassium current; rat cardiomyocytes},
language = {eng},
title = {Effect of Ajmaline on Action Potential and Ionic Currents in Rat Ventricular Myocytes with Focus on Transient Outward Current},
year = {2005}
}
TY - CONF
ID - 935639
AU - Bébarová, Markéta - Matejovič, Peter - Pásek, Michal - Šimurdová, Milena - Šimurda, Jiří
PY - 2005
TI - Effect of Ajmaline on Action Potential and Ionic Currents in Rat Ventricular Myocytes with Focus on Transient Outward Current
KW - ajmaline
KW - ionic current
KW - transient outward potassium current
KW - rat cardiomyocytes
N2 - We conclude that ajmaline is a potent blocker of IK(ATP), INa and Ito. In rat ventricular myocytes, block of INa is responsible for the decrease in upstroke velocity and the decline in AP amplitude. The main determinant of AP prolongation is block of Ito. Ajmaline is an open state blocker of Ito with fast recovery kinetics manifested in frequency independence of block.
ER -
BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Effect of Ajmaline on Action Potential and Ionic Currents in Rat Ventricular Myocytes with Focus on Transient Outward Current. In \textit{The 29th meeting of the European Working Group of Cardiac Cellular Electrophysiology, Antwerp (Belgium), 9. – 11. 9. 2005}. 2005.
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