C 2011

Gene polymorphisms in gingivitis

IZAKOVIČOVÁ HOLLÁ, Lydie, Kristína MUSILOVÁ, Jan VOKURKA, Pavla PANTUČKOVÁ, Lubomír KUKLA et. al.

Basic information

Original name

Gene polymorphisms in gingivitis

Name in Czech

Genové polymorfizmy u gingivitidy

Authors

IZAKOVIČOVÁ HOLLÁ, Lydie (203 Czech Republic, guarantor, belonging to the institution), Kristína MUSILOVÁ (203 Czech Republic, belonging to the institution), Jan VOKURKA (203 Czech Republic, belonging to the institution), Pavla PANTUČKOVÁ (203 Czech Republic, belonging to the institution), Lubomír KUKLA (203 Czech Republic, belonging to the institution), Martina KUKLETOVÁ (203 Czech Republic, belonging to the institution) and Zdeněk BROUKAL (203 Czech Republic, belonging to the institution)

Edition

1. vydání. Rijeka, Gingival Diseases - Their Aetiology, Prevention and Treatment, p. 203-230, 28 pp. 2011

Publisher

INTECH

Other information

Language

English

Type of outcome

Kapitola resp. kapitoly v odborné knize

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Croatia

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

RIV identification code

RIV/00216224:14110/11:00052207

Organization unit

Faculty of Medicine

ISBN

978-953-307-376-7

Keywords (in Czech)

gingivitida; genový polymorfizmus; parodontitida; zánět; děti

Keywords in English

gingivitis; gene polymorphism; periodontitis; inflammation; children

Tags

Reviewed
Změněno: 15/4/2012 11:23, Mgr. Michal Petr

Abstract

V originále

1) We aimed to conduct a review of the literature for gene polymorphisms associated with susceptibility to gingivitis. We searched the studies in English language using the key words gingivitis and gene (mutation or polymorphism) and analyzed their results. (a) Firstly, in introduction, etiopathogenesis and clinical picture of gingivitis were discussed, the role of genetics in this disease was analyzed and different approaches for genetic studies described. (b) Secondly, candidate genes in relation to gingivitis were analyzed and discussed in relation to various carriage rates of the rare (R)-allele, different environmental and other risk factors. 2) In addition, new data (still unpublished) about the role of interleukin-18 (IL-18) gene polymorphisms at positions -607C/A (rs1946518), -137G/C (rs187238) and -133C/G (rs360721) in relation to gingivitis and microbial pathogens in Czech children are presented in this chapter.

Links

NT11405, research and development project
Name: Mikrobiologické a genetické determinanty rozvoje a progrese parodontitidy u diabetiků 1. a 2. typu a jejich reciproční vztah ke kompenzaci diabetu
Investor: Ministry of Health of the CR
1M0528, research and development project
Name: Stomatologické výzkumné centrum
Investor: Ministry of Education, Youth and Sports of the CR, Dental research centre