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@proceedings{945511, author = {Knopfová, Lucia and Pekarčíková, Lucie and Beneš, Petr and Pernicová, Zuzana and Souček, Karel and Masařík, Michal and Šmarda, Jan}, booktitle = {Recent Advances in Colon Cancer Angiogenesis and Liver Metastasis}, keywords = {c-Myb; cell invasion; lung colonization; metastasis}, language = {eng}, title = {c-Myb-induced migration/invasiveness of breast and colon cells in vitro is not associated with enhanced lung colonization in vivo}, year = {2011} }
TY - CONF ID - 945511 AU - Knopfová, Lucia - Pekarčíková, Lucie - Beneš, Petr - Pernicová, Zuzana - Souček, Karel - Masařík, Michal - Šmarda, Jan PY - 2011 TI - c-Myb-induced migration/invasiveness of breast and colon cells in vitro is not associated with enhanced lung colonization in vivo KW - c-Myb KW - cell invasion KW - lung colonization KW - metastasis N2 - Metastasis formation and spread of primary tumors are the leading causes of death in cancer patients. To develop new treatment strategies, a clarification of the processes involved in the metastasis development is required. The c-Myb transcription factor is essential regulator of stem-progenitor cells in bone marrow, colon epithelia and neurogenic niches in brain. Malfunction of c-Myb results in malignancies of several types. The role of c-Myb in regulation of proliferation, differentiation and apoptosis is well established. In contrast, current knowledge on the role of c-Myb in control of metastasis formation remains poor. We have reported recently, that c-Myb promotes migration/invasion of human breast cancer MDA-MB-231 cells via upregulation of cathepsin D and MMP9. This study shows that overexpression of c-myb enhances migration and invasion of murine breast cancer 4T1 cells and murine colon cancer CT26 cells in vitro as well. ER -
KNOPFOVÁ, Lucia, Lucie PEKARČÍKOVÁ, Petr BENEŠ, Zuzana PERNICOVÁ, Karel SOUČEK, Michal MASAŘÍK and Jan ŠMARDA. c-Myb-induced migration/invasiveness of breast and colon cells in vitro is not associated with enhanced lung colonization in vivo. In \textit{Recent Advances in Colon Cancer Angiogenesis and Liver Metastasis}. 2011.
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