c-Myb-induced migration/invasiveness of breast and colon cells in vitro is not associated with enhanced lung colonization in vivo

KNOPFOVÁ, Lucia, Lucie PEKARČÍKOVÁ, Petr BENEŠ, Zuzana PERNICOVÁ, Karel SOUČEK, Michal MASAŘÍK and Jan ŠMARDA. c-Myb-induced migration/invasiveness of breast and colon cells in vitro is not associated with enhanced lung colonization in vivo. In Recent Advances in Colon Cancer Angiogenesis and Liver Metastasis. 2011.

Basic information

• Original name: c-Myb-induced migration/invasiveness of breast and colon cells in vitro is not associated with enhanced lung colonization in vivo
• Name in Czech: c-Myb-indukovaná migrace/invazivita buněk prsního a střevního karcinomu in vitro není spojená se zvýšenou kolonizací plic in vivo
• Authors: KNOPFOVÁ, Lucia (203 Czech Republic, belonging to the institution), Lucie PEKARČÍKOVÁ (203 Czech Republic, belonging to the institution), Petr BENEŠ (203 Czech Republic, belonging to the institution), Zuzana PERNICOVÁ (203 Czech Republic), Karel SOUČEK (203 Czech Republic), Michal MASAŘÍK (203 Czech Republic) and Jan ŠMARDA (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Recent Advances in Colon Cancer Angiogenesis and Liver Metastasis, 2011.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: Genetics and molecular biology
• Country of publisher: Canada
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14310/11:00049435
• Organization unit: Faculty of Science
• Keywords (in Czech): c-Myb; invazivita in vitro; kolonizace plic; metastázy
• Keywords in English: c-Myb; cell invasion; lung colonization; metastasis

Abstract

Metastasis formation and spread of primary tumors are the leading causes of death in cancer patients. To develop new treatment strategies, a clarification of the processes involved in the metastasis development is required. The c-Myb transcription factor is essential regulator of stem-progenitor cells in bone marrow, colon epithelia and neurogenic niches in brain. Malfunction of c-Myb results in malignancies of several types. The role of c-Myb in regulation of proliferation, differentiation and apoptosis is well established. In contrast, current knowledge on the role of c-Myb in control of metastasis formation remains poor. We have reported recently, that c-Myb promotes migration/invasion of human breast cancer MDA-MB-231 cells via upregulation of cathepsin D and MMP9. This study shows that overexpression of c-myb enhances migration and invasion of murine breast cancer 4T1 cells and murine colon cancer CT26 cells in vitro as well.

Abstract (in Czech)

c-Myb zvyšuje motilitu a invazivitu buněk prsního karcinomu 4T1 a buněk střevního karcinomu CT26. Výsledky experimentů in vivo, využívajících modelu experimentálních metastáz, ukazují, že zvýšená invazivita nádorových buněk in vitro není asociována se zvýšenou četností nádorových infiltrátů v plicích BALB/c myší in vivo.

Links

• GA301/09/1115, research and development project: Name: Úloha proteinů c-Myb a Cox-2 při tvorbě střevních nádorů

Investor: Czech Science Foundation, The role of c-Myb and Cox-2 proteins in colon carcinogenesis

• GD204/08/H054, research and development project: Name: Molekulární mechanismy proliferace a diferenciace buněk

Investor: Czech Science Foundation, Molecular mechanisms of the cell proliferation and differentiation

• IAA501630801, research and development project: Name: Mechanismus účinku prokatepsinu D na buňky rakoviny prsu

Investor: Academy of Sciences of the Czech Republic, Mechanism of procathepsin D effect on breast cancer cells

• MSM0021622415, plan (intention): Name: Molekulární podstata buněčných a tkáňových regulací

Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations