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@proceedings{945515,
author = {Linhartová, Petra and Marek, Filip and Kala, Zdeněk and Izakovičová Hollá, Lydie},
booktitle = {15th International Congress of Mucosal Immunology. Paris, France},
keywords = {interleukin-1, refluxní esofagitida, polymorfismy},
title = {Interleukin-1 Gene Polymorphisms Associated with Reflux Oesophagitis in the Czech Population},
year = {2011}
}
TY - CONF
ID - 945515
AU - Linhartová, Petra - Marek, Filip - Kala, Zdeněk - Izakovičová Hollá, Lydie
PY - 2011
TI - Interleukin-1 Gene Polymorphisms Associated with Reflux Oesophagitis in the Czech Population
KW - interleukin-1, refluxní esofagitida, polymorfismy
N2 - Reflux Oesophagitis (RO) is the subset of gastro-oesophageal reflux disease (GORD) with inflammation of the lower oesophagus due to acid gastric contents regurgitation. Polymorphisms in the interleukin-1 (IL-1) genes play a role in inflammatory diseases though the modulation of cytokine levels. The aim of this study was to associate the three variants in the IL-1 cluster with RO in the Czech population. In this case-control association study 131 patients with RO and 165 controls were genotyped using PCR-RFLP or PCR method for IL-1 gene polymorphisms [IL-1alpha (-889C/T), IL-1beta (+3953C/T), and IL-1RN (IL-1 receptor antagonist, VNTR)]. No significant differences were found in the allele and genotype frequencies of all polymorphisms between patients with RO and controls. Complex analysis revealed differences in IL-1 haplotype frequencies; the haplotype C(IL-1alpha-889)/C(IL-1beta+3953)/1(IL-1RN*1 allele) of the IL-1 gene cluster was significantly more frequent (54.8% vs. 43.7%, p=0.023) and the haplotype C(IL-1alpha-889)/C(IL-1beta+3953)/2(IL-1RN*2 allele) less frequent (11.9% vs. 21.2%, p=0.020) in RO patients than in controls. Although no significant role of single IL-1 variants in RO was found, our results suggest that different IL-1 haplotypes may be associated with increased or decreased susceptibility to RO. This study was supported by the project NPVII 2B06060, 1M0528 and IGA NT11405-6.
ER -
LINHARTOVÁ, Petra, Filip MAREK, Zdeněk KALA a Lydie IZAKOVIČOVÁ HOLLÁ. Interleukin-1 Gene Polymorphisms Associated with Reflux Oesophagitis in the Czech Population. In \textit{15th International Congress of Mucosal Immunology. Paris, France}. 2011.
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