Homogeneous diffusion layer model of dissolution incorporating the initial transient phase

ČUPERA, Jakub and Petr LÁNSKÝ. Homogeneous diffusion layer model of dissolution incorporating the initial transient phase. International Journal of Pharmaceutics. 2011, vol. 2011, No 416, p. 35-42. ISSN 0378-5173. Available from: https://dx.doi.org/10.1016/j.ijpharm.2011.05.081.

Basic information

Original name

Homogeneous diffusion layer model of dissolution incorporating the initial transient phase

Authors

ČUPERA, Jakub (203 Czech Republic, guarantor, belonging to the institution) and Petr LÁNSKÝ (203 Czech Republic, belonging to the institution)

Edition

International Journal of Pharmaceutics, 2011, 0378-5173

---

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10103 Statistics and probability

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.350

RIV identification code

RIV/00216224:14310/11:00052673

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.ijpharm.2011.05.081

UT WoS

000294790800005

Keywords in English

Dissolution; Sigmoidal profile; Random lag time; Dissolution variability

Tags

AKR, rivok

Tags

Reviewed

---

Abstract

V originále

We considered random lag time before the homogeneous phase of the dissolution begins. The resulting dissolution profiles are characterized by sigmoidal shape commonly observed in empirical dissolution data. Furthermore, probability distribution of repeated measurements at fixed time is deduced from the model and function describing variability of the data in dependency on time is proposed.