MYB transcriptionally regulates the miR-155 host gene in
chronic lymphocytic leukemia

J 2011

MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia

VARGOVÁ, Karin, Nikola CURIK, Pavel BURDA, Petra BAŠOVÁ, Vojtěch KULVAIT et. al.

Basic information

Original name

MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia

Name in Czech

MYB transkripčně reguluje miR-155 gen u chronické lymfatické leukémie

Authors

VARGOVÁ, Karin (203 Czech Republic), Nikola CURIK (203 Czech Republic), Pavel BURDA (203 Czech Republic), Petra BAŠOVÁ (203 Czech Republic), Vojtěch KULVAIT (203 Czech Republic), Vít POSPÍŠIL (203 Czech Republic), Filipp SAVVULIDI (203 Czech Republic), Juraj KOKAVEC (203 Czech Republic), Emanuel NEČAS (203 Czech Republic), Adéla BERKOVÁ (203 Czech Republic), Petra OBRTLÍKOVÁ (203 Czech Republic), Josef KARBAN (203 Czech Republic), Marek MRÁZ (203 Czech Republic, belonging to the institution), Šárka POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution), Jiří MAYER (203 Czech Republic, belonging to the institution), Marek TRNĚNÝ (203 Czech Republic), Jiří ZAVADIL (203 Czech Republic) and Tomáš STOPKA (203 Czech Republic, guarantor)

Edition

Blood, Washington, DC , USA, American Society of Hematology, 2011, 0006-4971

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 9.898

RIV identification code

RIV/00216224:14740/11:00056976

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1182/blood-2010-05-285064

UT WoS

000289265500017

Keywords in English

MYB; CLL; miR-155 host gene; B-CLL

Abstract

ORIG CZ

V originále

Elevated levels of microRNA miR-155 represent a candidate pathogenic factor in chronic B-lymphocytic leukemia (B-CLL). In this study, we present evidence that MYB (v-myb myeloblastosis viral oncogene homolog) is overexpressed in a subset of B-CLL patients. MYB physically associates with the promoter of miR-155 host gene (MIR155HG, also known as BIC, B-cell integration cluster) and stimulates its transcription. This coincides with the hypermethylated histone H3K4 residue and spread hyperacetylation of H3K9 at MIR155HG promoter. Our data provide evidence of oncogenic activities of MYB in B-CLL that include its stimulatory role in MIR155HG transcription.

In Czech

Zvýšené množství microRNA miR-155 representuje kandidátní patogenetický faktor u chronické lymfatické leukémie. V této studii demonstrujeme, že MYB (v-myb myeloblastosis viral oncogene homolog) je zvýšeně exprimován u subtypu CLL paciemtů. MYB je fyzicky asociován s promotorem genu obsahujícího miR-155 (MIR155HG, také znám jako BIC) a stimuluje jeho transkripci.

Links

NT11218, research and development project

Name: Funkční a strukturní změny microRNA u lymfoproliferativních malignit a jejich vliv na prognózu onemocnění a predikci léčebné odpovědi

Citovat

VARGOVÁ, Karin, Nikola CURIK, Pavel BURDA, Petra BAŠOVÁ, Vojtěch KULVAIT, Vít POSPÍŠIL, Filipp SAVVULIDI, Juraj KOKAVEC, Emanuel NEČAS, Adéla BERKOVÁ, Petra OBRTLÍKOVÁ, Josef KARBAN, Marek MRÁZ, Šárka POSPÍŠILOVÁ, Jiří MAYER, Marek TRNĚNÝ, Jiří ZAVADIL and Tomáš STOPKA. MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. Blood. Washington, DC , USA: American Society of Hematology, 2011, vol. 117, No 14, p. 3816-3825. ISSN 0006-4971. Available from: https://dx.doi.org/10.1182/blood-2010-05-285064.

@article{945694,
   author = {Vargová, Karin and Curik, Nikola and Burda, Pavel and Bašová, Petra and Kulvait, Vojtěch and Pospíšil, Vít and Savvulidi, Filipp and Kokavec, Juraj and Nečas, Emanuel and Berková, Adéla and Obrtlíková, Petra and Karban, Josef and Mráz, Marek and Pospíšilová, Šárka and Mayer, Jiří and Trněný, Marek and Zavadil, Jiří and Stopka, Tomáš},
   article_location = {Washington, DC , USA},
   article_number = {14},
   doi = {http://dx.doi.org/10.1182/blood-2010-05-285064},
   keywords = {MYB; CLL; miR-155 host gene; B-CLL},
   language = {eng},
   issn = {0006-4971},
   journal = {Blood},
   title = {MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia},
   volume = {117},
   year = {2011}
}

TY  - JOUR
ID  - 945694
AU  - Vargová, Karin - Curik, Nikola - Burda, Pavel - Bašová, Petra - Kulvait, Vojtěch - Pospíšil, Vít - Savvulidi, Filipp - Kokavec, Juraj - Nečas, Emanuel - Berková, Adéla - Obrtlíková, Petra - Karban, Josef - Mráz, Marek - Pospíšilová, Šárka - Mayer, Jiří - Trněný, Marek - Zavadil, Jiří - Stopka, Tomáš
PY  - 2011
TI  - MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia
JF  - Blood
VL  - 117
IS  - 14
SP  - 3816-3825
EP  - 3816-3825
PB  - American Society of Hematology
SN  - 00064971
KW  - MYB
KW  - CLL
KW  - miR-155 host gene
KW  - B-CLL
N2  - Elevated levels of microRNA miR-155 represent a candidate pathogenic factor in chronic B-lymphocytic leukemia (B-CLL). In this study, we present evidence that MYB (v-myb myeloblastosis viral oncogene homolog) is overexpressed in a subset of B-CLL patients. MYB physically associates with the promoter of miR-155 host gene (MIR155HG, also known as BIC, B-cell integration cluster) and stimulates its transcription. This coincides with the hypermethylated histone H3K4 residue and spread hyperacetylation of H3K9 at MIR155HG promoter. Our data provide evidence of oncogenic activities of MYB in B-CLL that include its stimulatory role in MIR155HG transcription.
ER  -

VARGOVÁ, Karin, Nikola CURIK, Pavel BURDA, Petra BAŠOVÁ, Vojtěch KULVAIT, Vít POSPÍŠIL, Filipp SAVVULIDI, Juraj KOKAVEC, Emanuel NEČAS, Adéla BERKOVÁ, Petra OBRTLÍKOVÁ, Josef KARBAN, Marek MRÁZ, Šárka POSPÍŠILOVÁ, Jiří MAYER, Marek TRNĚNÝ, Jiří ZAVADIL and Tomáš STOPKA. MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. \textit{Blood}. Washington, DC , USA: American Society of Hematology, 2011, vol.~117, No~14, p.~3816-3825. ISSN~0006-4971. Available from: https://dx.doi.org/10.1182/blood-2010-05-285064.

Detailed Information on Publication Record